Cancer human neuroendocrine

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SST receptors have been identilied in vitro on the membrane of a variety of tumor cells, especially in neuroendocrine tumors, tumors of the nervous system, lymphomas, breast cancers, prostate cancers, gastric cancers, and so on (116,117). In addition, some human tumors (such as colorectal cancers) that exhibit no detectable SST receptor still have a high receptor density in vascular systems surrounding the tumor tissues (119). 

Immunohistochemical studies relate polysialic acid-NCAM expression to tumor malignancy in neuroblastoma, alveolar rhabdomyosarcoma [189], neuroendocrine lung tumors [190], Wilm s tumor [191], aggressive colon cancers [192], and pancreatic cancer [193]. In studies on the role of polysialic acid in tumor cell behavior, endosialidase has been used as a tool to remove polysialic acid from the surface of cells and tumors. In a metastasis model using human rhabdomyosarcoma TE671 cells, endoNA injected intraperitoneally reduces the expression of polysialic acid and the number of lung and liver metastases formed from intraperi-toneal primary tumors [194]. For comparison, the effect was not seen with intramuscular primary tumors that cannot be reached by the intraperitoneally injected endosialidase. 

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