Cancer from oils

Mehlman MA. 1991. Dangerous and cancer-causing properties of products and chemicals in the oil refining and petrochemical industry Part VI—human health and environmental hazards resulting from oil and oil products. Journal of Clean Technology and Environmental Sciences 1 103-121. 

Toxicology. Used mineral-based crankcase oil poses a primary risk of skin cancer from frequent and prolonged contact and is minimally irritating to the respiratory tract. 

Alkaloid from P. villatus and C. lepadiformis. Exhibits significant in vitro cytotoxicity against human cancer cells. Oil. [ajf) + 15 (MeOH). 

Skin cancer from work involving exposure to mineral oil. 

Since many essential nutrients (e.g., monosaccharides, amino acids, and vitamins) are water-soluble, they have low oil/water partition coefficients, which would suggest poor absorption from the GIT. However, to ensure adequate uptake of these materials from food, the intestine has developed specialized absorption mechanisms that depend on membrane participation and require the compound to have a specific chemical structure. Since these processes are discussed in Chapter 4, we will not dwell on them here. This carrier transport mechanism is illustrated in Fig. 9C. Absorption by a specialized carrier mechanism (from the rat intestine) has been shown to exist for several agents used in cancer chemotherapy (5-fluorouracil and 5-bromouracil) [37,38], which may be considered false nutrients in that their chemical structures are very similar to essential nutrients for which the intestine has a specialized transport mechanism. It would be instructive to examine some studies concerned with riboflavin and ascorbic acid absorption in humans, as these illustrate how one may treat urine data to explore the mechanism of absorption. If a compound is... 

CAS = Chemical Abstracts Services DOT/UN/NA/IMCO = Department of Transportation/United Nations/ North America/lnternational Maritime Dangerous Goods Code EPA = Environmental Protection Agency HSDB a Hazardous Substance Data Bank from National Library of Medicine NCI = National Cancer Institute NIOSH = National Institute for Occupational Safety and Health OHM-TADS = Oil and Hazardous Materials/Technical Assistance Data System RTECS = Registry of Toxic Effects of Chemical Substances... 

Petroleum hydrocarbons (oil and combustion by-products such as PAHs) Runoff and atmospheric deposition from land activities shipping and tanker operations accidental spills, coastal and offshore oil and gas production natural seepage Toxic effects including birth defects, cancer, and systemic poisoning. Tar balls degrade beach habitat. 

He shou wu, a herhal formulation has been used for the treatment of skin tumors. For topical use, the powder is mixed with sesame oil and applied. He shou wu has been used for centuries to help maintain the youthful color of one s hair and also to help diminish hair loss. Holy basil contains ursolic acid (Fig. 7) — one of the cosmetic industry s latest favorites because not only does it quickly heal the skin, it also improves elasticity and removes wrinkles. It also shows benefits for preventing skin cancer. A poultice made from the herh is used topically for its antifungal and antibacterial actions. ... 

As everyone knows, plants have been used for centuries in herbalism, homeopathy, and aromatherapy because of their medicinal qualities. The long-term use of plants has led to recent observations about their antioxidant properties (1, 2). Many scientists have observed antioxidant activities in compounds derived from the volatile constituents (3, 4) and essential oil extracts - of plants. They have reported that ingestion of these volatile chemicals can prevent lipid peroxidation, which is associated with diseases such as cancer, leukemia, and arthritis. In the present study, analysis and antioxidative tests on the volatile extract isolated from a commercial beer were performed. Why did we choose beer We chose beer because... 

Certain industrial populations exposed to coal tar products have a demonstrated risk of skin cancer. Substances containing polycyclic hydrocarbons or polynuclear aromatics (PNAs), which may produce skin cancer, also produce contact dermatitis (e.g., coal tar pitch, cutting oils)." Although allergic dermatitis is readily induced by PNAs in guinea pigs, it only rarely is reported in humans from occupational contact with PNAs. Incidences in humans have resulted largely from the therapeutic use of coal tar preparations. ... 

BPL applied to mouse skin one to seven times (over a period of 2 weeks) as undiluted BPL or in solutions of corn oil or acetone at doses of 0.8-100 mg caused skin irritation the effects ranged from erythema to hair loss and scarring. Lifetime painting (3 times/week) with acetone and corn oil solutions showed that BPL produced both papillomas and cancer of the mouse skin 0.2 5 mg in acetone caused papillomas in 12 of 30 animals and cancers in 3, whereas 5 mg produced tumors in 21 of 30 animals and cancers in 11. In corn oil, 0.8 mg caused tumors in 27 of 30 mice 12 of the tumors were malignant. Papillomas developed in 11 of 90 and 14 of 80 of the acetone and corn oil control groups, respectively. ... 

The industrial revolution of the late nineteenth and early twentieth century brought clear confirmation that occupational exposure to chemicals could cause cancer. The first indication came from increases in skin and bladder cancers associated with cutting oils and dyes. In 1895 bladder cancer was associated with workers in the aniline dye industry. Further worker-based studies found that exposure to... 

The essential task of modern biotechnology is to change an organism s genetic material (DNA) to allow for the production of a useful protein. The gene for the protein must first be isolated and engineered so that it will drive production of the protein. The product may be the protein, or it may be a modified organism, such as a bacterium that cleans up oil spills, a tree that removes mercury from contaminated sod, or a virus that treats cancer. 

---