Toxicology potential

Asoc inol. Asocainol, a diben2azonine derivative, has sodium channel (Class I) and calcium channel (Class IV) blocking activity that accounts for the antiarrhythmic activity. Preliminary studies indicate that the compound is effective against ventricular arrhythmias (88). Additional studies are needed to estabUsh efficacy, toxicological potential, and pharmacokinetic profile. 

Davies, J.E., Enos, H.F., Barquet, A., Morgade, C., and Danauskas, J.X. (1979) Developments in toxicology and environmental sciences pesticide monitoring studies. The epidemiologic and toxicologic potential of urinary metabolites, in Toxicology and Occupational Medicine, Deichman, W.B., Ed., pp. 369-380. 

Steiner S et al. Expression profiling in toxicology - potentials and limitations. Toxicol Lett 2000 112-113 467 171. 

The US Food and Drug Administration (FDA) has recently proposed an approach to the safety assessment of bound residues derived from carcinogenic drugs thought to be both scientifically valid and reasonably capable of being accomplished (20, 21). This approach is based on the data collected from a combination of both in vitro and in vivo tests in the areas of the bioavailability and toxicological potential of bound residues, the reversibility of adduct formation, and the mechanism of bound residue formation. 

Nohava, M., W.R. Vogel, and H. Gaugitisch. 1995. Evaluation of the luminescent bacteria bioassay for the estimation of the toxicological potential of effluent water samples—comparison with data from chemical analyses. Environ. Int. 21 33-37. 

Steiner S, Anderson NL. 2000. Expression profihng in toxicology—potentials and limitations. Toxicol Lett 112-113(8) 467 71. 

Steiner, S. and Anderson, N. L. (2000) Expression profiling in toxicology— potentials and limitations. Toxicol. Lett. 112-113, 467 71. 

Clinical trialists should be careful not to ignore the toxicological potential of the often large amounts of vehicle (ionic strengths, buffering materials, extreme pH) that may be required to maintain complex peptides in a stable form. These can include unanticipated allergens, nephrotoxins and hepatotoxins. 

Toxicology Potential skin, eye, and respiratory tract irritant may be harmful if swallowed prolonged eye/skin contact may cause severe irritation N-vinyl pyrrolidone caused liver damage in animals Precaution Incompat. with oxidizers, acids, alkaline materials, free radical generators avoid excessive heat, ignition sources Hazardous Decomp. Prods. CO NO, may emit toxic fumes on thermal decomp. 

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