Cancer brain tumor

PIAS3 SUMO (E3) iigase Lung cancer, breast cancer, prostrate cancer, coiorectai cancer, brain tumor 392... 

Radiosensitizing Abilities of the Taxanes Application in the Clinic Nonsmall-Cell Lung Cancer Small-Cell Lung Cancer Brain Tumors Genitourinary Cancers Gynecological Cancers Breast... 

Cancer. There is no specific evidence from epidemiological studies that diazinon causes cancer in humans. Several studies have reported an increased incidence of cancers (brain tumors, Hodgkin s lymphoma, multiple myelomas) in humans who were concurrently or sequentially exposed to a number of insecticides, including diazinon (Cantor et al. 1992 Davis et al. 1993 Morris et al. 1986). However, it is not possible to attribute the increase in cancer incidence exclusively to diazinon exposure. Consequently, while the findings in these studies suggest an elevated risk for the cancers from high exposure to insecticides, in general, the data are far too limited to be used to evaluate the potential for diazinon to cause cancer in humans. 

Head and Neck Cancers Brain Tumors Mesothelioma... 

Photofrin (polyhematoporphyrin ethers), the first and so far only photosensitizer approved by health agencies worldwide for treatment of cancer, remains the most widely used in routine clinical practice for treatment of esophageal and lung cancers (approved), as well as in a host of off-label indications (e.g., skin cancer, bladder cancer, brain tumors, head and neck cancers, etc). 

Cancer chemothCTapeutic agents as a rule poorly penetrate the blood brain barrier. Brain tumors are thus not readily treatable by chemotherapy. Diaziquone (at one time known as AZQ) is an exception to this generalization. Treatment of chloranil (213) with the anion from urethane gives intermediate 214, probably by an addition elimination scheme. Displacement of the remaining halogen with aziridine yields diaziquone (215) [.55J. 

Cancer Neuroblastoma, leukemia, brain tumors and prostate cancer (A) ... 

Cornetta K, Croop J, Dropcho E, Abonour R, Kieran MW, Kreissman S, Reeves L, Erickson LC, Williams DA (2006) A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34-I- peripheral blood cells with 06-methylguanine DNA methyltransferase. Cancer Gene Ther 13 886-895... 

Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, AUen M et al (2007) A perivascular niche for brain tumor stem cells. Cancer Cell 11 69-82... 

Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB (2007) Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res... 

Vincristine (VCR, Oncovin) ALL HD NHL multiple myeloma breast cancer SCLC, KS brain tumors soft tissue sarcomas osteosarcomas neuroblastoma Wilms tumor... 

Chen X, Conti PS, Moats RA (2004) In vivo near-infrared fluorescence imaging of integrin av(33 in brain tumor xenografts. Cancer Res 64 8009-8014... 

Cheung W, Darfler M, Alvarez H, et al. Apphcation of a global proteomic approach to archival precursor lesions deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancers. Pancreatology 2008 8 608-616. 

Aliosman, F., Caughlan, J., and Gray, G.S. (1989) Diseased DNA intrastrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-fcis(2-chlorocthyl)-1 -nitrosourea after in vitro reaction with glutathione. Cancer Res. 49, 5954. 

Metal-texaphyrin complexes such as 55 selectively accumulate in tumor cells (240) (see Section III). Complex 55 readily undergoes aone-electron reduction (Ei/2 = 0.08 V vs NHE), forming a free radical which is capable of damaging DNA. Because of the high electron affinity of 55, it may prolong the lifetime of HO- radicals formed by radiolysis of water. Complex 55 is now in phase II clinical trials for the treatment of brain tumors and lung, head, neck, and pancreatic cancer. 

Hemmati, H., Nakano, L, Lazareff, J., Masterman-Smith, M., Geschwind, D., Bronner-Fraser, M. and Kornblum, H. (2003) Cancerous stem cells aris from pediatric brain tumors. Proc. Nad. Acad. Scl USA 100, 15178-15183. 

Vexcovi, A., Galli, R. and Reynolds, B. (2006) Brain tumor stem cells. Nat Rev Cancer 6, 425-436. 

CEO, Stephen Hoffman and VP for clinical studies, Michael Gerber of Alios Therapeutics guided RSR 13 through a series of phase-one and phase-two clinical trials for radiation treatment of brain tumors and for potential use in cardiopulmonary bypass surgery [46, 51-55]. Considering the cost of running a phase-three clinical trial, only one was possible. The very positive phase-two results for use of RSR 13 to treat metastatic brain cancer provided the impetus for selecting that indication for a phase-three trial. 

The study of the Central Nervous System (CNS) is the primary clinical indication for the use of extracellular Gd(III) agents. The majority of these pathologies are brain tumors, and three quarters of them are represented by metastases occurring in patients undergoing treatment for systemic cancer (Fig. 1). Other brain diseases, such as multiple sclerosis and cerebral injuries can be also investigated by contrast-enhanced MRI. 

Inaeased risk of various cancers (e.g., lymphatics, blood, stomach, prostate, testes, brain, and soft tissues) was reported upon exposure to pesticides (Zahm and Blair 1993 Hayes et al. 1995 Zahm et al. 1997). Children s cancer, including brain tumors, leukemia, non-Hodgkin s lymphoma, sarcoma, and Wilms tumor due to direct or parental exposure to pesticides also has been determined (Fear et al. 1998 Kristensen et al. 1996 Pogoda and Preston-Martin 1997 Sharpe et al. 1995 Buckley et al. 1994). Often, the risk of cancer due to exposure to pesticides has been higher in children than in adults (Zahm and Ward 1998). Moreover, birth defects, including limb-reduction defects, have been linked to exposures to pesticides (Restrepo et al. 1990 Schwartz and LoGerfo 1998 Lin et al. 1994), as has a higher-than-normal risk of stillborn births (Pastore et al. 1997). 

In humans methylene chloride exposure has been associated with a wide variety of cancers in a number of cohort and case control studies pancreatic, prostate, lung, liver, cervical, breast, and astrocytic brain tumors have been reported. Limitations in these studies include small sample size, incomplete exposure information, and concomitant exposure to other carcinogenic substances. The lARC has stated that there is not a sufficiently consistent elevation of risk across studies to make a causal interpretation credible. In a recent study of 1473 workers, followed for nearly 50 years, methylene chloride exposure level was not related to mortality due to all causes, malignant neoplasms, or lung and pancreatic cancers. ... 

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