Cancer Neuroblastoma

Cancer Neuroblastoma, leukemia, brain tumors and prostate cancer (A) ... 

There is a school of thought, which believes that HMTases are tumor suppressors especially the lysine methyltransferases because of the loss of SET domain proteins in tumor conditions, exceptions do exist like Ezh2. The well-known example of the above is RIZl, which interacts with Rb protein (again the same tumor suppressor). RIZ-1 is in chromosome lp36 region, which is commonly deleted, in more than a dozen different types of human cancers. Riz-1 expression is commonly silenced in many tumors including breast cancer, liver cancer, colon cancer, neuroblastoma, melanoma, lung cancer and osteosarcoma (Kim et al, 2003). 

Anthracyclines Doxorubicin/ adriamycin Melanoma, Ovarian carcinoma, T-cell lymphoma, Colon carcinoma, B-cell lymphoma, Various disseminated refractory malignandes, Breast cancer, Lung cancer, Pancreatic cancer, Liver cancer, Neuroblastoma... 

CCK receptors SCLC, pancreatic cancers, neuroblastomas, meningiomas, medullary thyroid carcinomas... 

This drag is used for leukemia, various sarcomas, practically every type of cancer, neuroblastomas, leukoses, and lymphomas. Synonyms of this drag are adriacin, adriablastin, and others. 

Clinical uses Leukemia, lymphoma, multiple myeloma, sarcomas, germ cell tumors of ovaries or testes, head and neck cancer, lung cancer, Wilms tumor, breast cancer, stomach cancer, pancreatic cancer, liver cancer, ovarian cancer, bladder cancer, uterine cancer, neuroblastoma. 

N-MYC gastric, and lung cancers Neuroblastoma, small cell lung... 

Acute myelogenous and acute lymphocytic leukemia Soft-tissue, osteogenic, and other sarcoma Hodgkin s disease non-Hodgkin s lymphoma acute leukemia breast, genitourinary, thyroid, lung, stomach cancer neuroblastoma and other childhood sarcomas... 

Cyclophosphamide 1 i i i 1 Alkylating agent— attacks guanine N7— dysfunctional DNA Non-Hodgkin, ovarian, breast cancer, neuroblastoma BMS, mucositis, hemorrhagic cystitis (mesna, traps acrolein and is protective), hepatotoxicity (high dose)... 

Reports of ChE abnormalities in tumours, e.g., meningioma, glioma, acoustic neurinomas and lung cancers, megakaryocytopoietic disorders and leukemias, ovarian tumours and neuroblastomas, suggest cell proliferation and differentiation activities. 

Extrahypothalamic OX-B-like immunoreactivity, reminiscent to that of CRF, has been described in clustered GABAergic neuronal populations, in the lateral division of central nucleus ofthe amygdala, the bednucleus of the stria terminalis, and in the hippocampus. Moreover, ectopic expression of preproorexin mRNA in the gut, ependymal cells, neuroblastomas, and of orexin receptors in adrenal gland, cancer and hematopietic stem cells suggests yet unexplored roles of orexins as paracrine factors controlling blood-brain barrier, and tumor or stem cell function. 

N-MYC Neuroblastoma, small cell lung cancer, and glioblastoma... 

Vincristine (VCR, Oncovin) ALL HD NHL multiple myeloma breast cancer SCLC, KS brain tumors soft tissue sarcomas osteosarcomas neuroblastoma Wilms tumor... 

Cancers Multiple myeloma Non-Hodgkin s lymphoma Hodgkin s disease Acute myeloid leukemia Neuroblastoma Germ cell tumors Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Myelodysplastic syndrome Myeloproliferative disorders Non-Hodgkin s lymphoma Hodgkin s disease Chronic lymphocytic leukemia Multiple myeloma... 

Airoldi I, Raffaghello L, Piovan E, et al. CXCL12 does not attract CXCR4+ human metastatic neuroblastoma cells clinical implications. Clin Cancer Res 2006 12 77-82. 

SH-SY5Y neuroblastoma, cisplatin-sensitive A2780 and cispla-tin-resistant A2780cis human ovarian cancer cells was observed, but upon irradiation 7 strongly reduced the viability of the cancer cells (Fig. 8). In the A2780 cell line, the complex was 80x more toxic than cisplatin under identical conditions, and ca. 15 x more effective against the cisplatin-resistant A2780cis cell line (33). The trans diazido-Pt(IV) complex therefore has remarkable cytotoxic properties. 

Andre N, Braguer D, Brasseur G, et al. Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells. Cancer Res 2000 60(19) 5349-5353. 

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