Calcium blood pressure reduction

The nondihydropyridine calcium channel blockers have been shown to also decrease protein excretion in patients with diabetes,20 but the reduction in proteinuria appears to be related to the reductions in blood pressure. The maximal effect of nondihydropyridine calcium channel blockers on proteinuria is seen with a blood pressure reduction to less than 130/80 mm Hg and no additional benefit is seen with increased doses. Dihydropyridine calcium channel blockers, however, do not have the same effects on protein excretion, and may actually worsen protein excretion.17... 

At relatively low concentrations, lead produces relatively modest or short-term effects, including elevation of blood pressure, reduction in the synthesis of hemoglobin, and decreased ability to utilize vitamin D and calcium. With increased blood concentrations of lead, however, these problems become more severe. Impairment of the central nervous system can occur, with decreased mental functioning and hearing damage as two possible results. At very high lead concentrations, a person can fall into a coma and, eventually, die. 

Dilitiazem hydrochloride is a calcium antagonist hypertension drug. It produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in perepheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension. 

I, 1,1 -trichloroethane and other halogenated hydrocarbons are generally supportive and rely on the body s ability to eliminate rapidly 1,1,1-trichloroethane and its metabolites. Animal studies indicate that intravenous injection or infusion of calcium gluconate or phenylephrine are protective against acute blood pressure reduction caused by exposure to 1,1,1-trichloroethane (Herd et al. 1974). Further animal testing is needed to assess whether these compounds might be used to resuscitate individuals exposed to high concentrations of 1,1,1-trichloroethane. 

The mechanism of action of ranolazine has not been determined, but it may be related to reduction in calcium overload in ischemic myocytes through inhibition of the late sodium current. Its antianginal effects do not depend on reductions in HR or blood pressure. 

Obviously, the effects of tamoxifen and derivatives and of raloxifene on L-type calcium channels from aortic and other blood vessels would reduce vascular smooth muscle contractility. This action, in synergy with the aforementioned effect on BK channels, would reduce blood peripheral resistance and blood pressure, which may partially account for the reduction in cardiovascular risk (Da Costa et al. 2004 Trump et al. 1992) (Fig. 4.1). 

Urine volume, creatinine clearance, BUN, electrolytes, reduction in edema, increased diuresis, decrease in body weight, reduction in blood pressure, glucose, uricacid, serum calcium (tetany), tinnitus, vertigo, hearing loss (especiallyin those at risk for ototoxicity—IV doses > 120 mg concomitant ototoxic drugs renal disease)... 

Most types of smooth muscle are dependent on transmembrane calcium influx for normal resting tone and contractile responses. These cells are relaxed by the calcium channel blockers (Figure 12-3). Vascular smooth muscle appears to be the most sensitive, but similar relaxation can be shown for bronchiolar, gastrointestinal, and uterine smooth muscle. In the vascular system, arterioles appear to be more sensitive than veins orthostatic hypotension is not a common adverse effect. Blood pressure is reduced with all calcium channel blockers. Women may be more sensitive than men to the hypotensive action of diltiazem. The reduction in peripheral vascular resistance is one mechanism by which these agents may benefit the patient with angina of effort. Reduction of coronary artery tone has been demonstrated in patients with variant angina. 

Belizan, J. M., Villar, J., Pineda, 0., Gonzales, A. E., Sainz, E., Garrera, G, and Sibrian, R. 1983A. Reduction of blood pressure with calcium supplementation in young adults. JAMA 249, 1161-1165. 

Evolus Calcium-enriched fermented milk drink (3-casein, Val-Pro-Pro, Ile-Pro-Pro Reduction of blood pressure Valio Oy, Finland Seppo et al. (2002, 2003)... 

Cardiovascular In rodents, lymphohistiocytic infiltrates have been observed in the heart and in the perivascular space in various organs. Tissue macrophages in the heart can contain basophilic granules. In monkeys, no changes in ECG, heart rate, or blood pressure have been observed with numerous oligonucleotides. Under conditions when complement is activated, changes in blood pressure and cardiovascular collapse due to hypotension have been observed [55], but we have shown this to be related to complement activation rather than a direct effect on the cardiovascular system. (Of course, other mechanisms for hypotension could occur with other chemistries. For example, if an oligonucleotide formulation or its metabolic products chelates calcium, reductions in ionizable calcium could also produce a hypotensive crisis.) For most PS ODNs the most likely cause of hypotension is complement activation as demonstrated with complement inhibitors. 

It has been suggested that calcium channel blockers can be used to treat cocaine dependence, and some studies have shown reductions in cocaine-induced subjective and cardiovascular responses with nifedipine and diltiazem. The cardiovascular and subjective responses to cocaine have been evaluated in a double-blind, placebo-controlled, crossover study in five subjects pretreated with two dosage of nimodipine (393). Nimodipine 60 mg attenuated the rise in systolic, but not diastolic, blood pressure after cocaine. In three subjects nimodipine 90 mg produced greater attenuation than 60 mg. The subjective effects of cocaine were not altered by either dose of nimodipine. 

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