Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Renal drugs

The renal clearance can be under estimated in the case of renal drug metabolism. The total drug clearance depends on bioavailability. Therefore, the most reliable estimate for the fraction eliminated by the renal route (fren) is given by the normal clearance (Clnorm) and drug clearance in case of acute and/ or chronic renal failure (Clfail), or from half-lives (Tl/2norm) and (Tl/2fail). [Pg.957]

Within the OAT family, OAT4 is the only transporter expressed at appreciable levels in both the placenta and in the kidney [54]. The membrane localization of OAT4 within these tissues has not been examined. Steroid sulfates, and ochratoxinA are efficient transport substrates of OAT4, whereas PAH is weakly transported [54]. The functional importance of OAT4 in regulating placental permeability and renal drug elimination is currently unknown. [Pg.191]

Susaki, H., Suzuki, K., Ikeda, M., Yamada, H., and Watanabe, H.K. (1998) Renal drug targeting using a vector alkylglycoside . Chem. Pharm. Bull. 46, 1530-1537. [Pg.1119]

The mesangial cells of the glomerulus and the proximal tubular cells are the first choice targets for renal drug delivery. Both cell types play a central role in many disease processes in the kidney. [Pg.124]

It is important to appreciate that these tubular transport mechanisms are not as well developed in the neonate as in the adult. In addition, their functional capacity may be diminished in the elderly. Thus, compounds normally eliminated by tubular secretion will be excreted more slowly in the very young and in the older adult. This age dependence of the rate of renal drug secretion may have important therapeutic implications and must be considered by the physician who prescribes drugs for these age groups. [Pg.42]

An important pharmacokinetic change that occurs in persons of advanced age is that of reduced renal drug elimination,... [Pg.1378]

The renal drug clearance is influenced by alterations in glomerular filtration rate and tubular reabsorption or secretion rate. [Pg.53]

Section III. Cardiovascular-Renal Drugs Chapter ll Antihypertensive Agents... [Pg.6]

For women, the result should be multiplied by 0.85 (because of reduced muscle mass). It must be emphasized that this estimate is, at best, a population estimate and may not apply to a particular patient. If the patient has normal renal function (up to one third of elderly patients), a dose corrected on the basis of this estimate will be too low—but a low dose is initially desirable if one is uncertain of the renal function in any patient. If a precise measure is needed, a standard 12- or 24-hour creatinine clearance determination should be obtained. As indicated above, nutritional changes alter pharmacokinetic parameters. A patient who is severely dehydrated (not uncommon in patients with stroke or other motor impairment) may have an additional marked reduction in renal drug clearance that is completely reversible by rehydration. [Pg.1275]

Runge-Morris, M., Feng, Y, Zangar, R.C. Novak, R.F. (1996) Effects of hydrazine, phenelzine, and hydralazine treatment on rat hepatic and renal drug-metabolizing enzyme expression. DrugMetab. Disp., 24, 734-737... [Pg.1011]

Kapur G, Mattoo T, Aranda JV. Pharmacogenomics and renal drug disposition in the newborn. Semin Perinatol. 2004 28 132-140. [Pg.38]

Lee W, Kim RB. Transporters and renal drug elimination. Annu Rev Pharmacol Toxicol. 2004 44 137-166. [Pg.38]

Perri D, Ito S, Rowsell V, Shear NH. The kidney—the body s playground for drugs an overview of renal drug handling with selected clinical correlates. Can J Clin Phartnacol. 2003 10 17-23. [Pg.38]

The U.S. Centers for Disease Control (CDC) and the National Center for Health Statistics (NCHS) report that cardiovascular-renal drugs (including diuretics, beta blockers, and calcium channel blockers) were the most frequently prescribed medications in the United States in 1999 (the most recent year for which data was available). In fact, the loop diuretic Lasix was the second most frequently prescribed medication overall, with more than 12.9 million prescriptions written. It was second only to the allergy drug Claritin. [Pg.175]

Katzung PHARMACOLOGY, 9e > Section IE. Cardiovascular-Renal Drugs > Chapter 11. Antihypertensive Agents > ... [Pg.256]

The contraindications to the use of 6-blockers are asthma and other bronchospastic conditions, severe bradycardia, atrioventricular blockade, bradycardia-tachycardia syndrome, and severe unstable left ventricular failure. Potential complications include fatigue, impaired exercise tolerance, insomnia, unpleasant dreams, worsening of claudication, and erectile dysfunction. Katzung PHARMACOLOGY, 9e > Section III. Cardiovascular-Renal Drugs > Chapter 12. Vasodilators the Treatment of Angina Pectoris > ... [Pg.281]


See other pages where Renal drugs is mentioned: [Pg.889]    [Pg.396]    [Pg.371]    [Pg.550]    [Pg.551]    [Pg.124]    [Pg.132]    [Pg.135]    [Pg.139]    [Pg.141]    [Pg.144]    [Pg.278]    [Pg.189]    [Pg.199]    [Pg.102]    [Pg.187]    [Pg.207]    [Pg.1383]    [Pg.261]    [Pg.2]    [Pg.72]    [Pg.74]    [Pg.22]    [Pg.30]    [Pg.68]    [Pg.225]   


SEARCH



Acute renal failure, drug metabolism

Adverse drug reactions impaired renal function

Adverse drug reactions renal

Adverse drug reactions renal disease

Chronic renal failure, drug metabolism

Drug absorption, pharmacokinetic renal disease

Drug biotransformation renal

Drug disposition in renal failure

Drug distribution , volume renal disease

Drug dosage in renal failure

Drug elimination renal excretion

Drug metabolism renal

Drug metabolism, pharmacokinetic renal disease

Drug therapy renal changes

Drug therapy renal clearance

Drug therapy renal function

Drug-induced renal disease

Drugs that Can Increase the Risk of Renal Failure

Effects of Renal Disease on Drug Absorption

Fenoldopam, an oral drug, is more potent than dopamine in causing renal vasodilation without having adrenergic, cholinergic, or histaminergic properties

Neonates renal drug elimination

Neonates renal drug excretion

Nonsteroidal anti-inflammatory drugs renal effects

Renal Clearance and Drug Design

Renal Handling of Drugs

Renal Specificity of Amino Acid Pro-drug and their Effects

Renal clearance, of drugs

Renal disease drug elimination

Renal disease drug-related

Renal disease, drug contraindications

Renal drug clearance

Renal drug elimination

Renal drug excretion acceleration

Renal drug transporters

Renal drugs drug information sources

Renal dysfunction drug therapy

Renal effects therapeutic drug monitoring

Renal elimination, drugs, effect

Renal excretion of drugs

Renal excretion, drugs

Renal failure drug-induced

Renal failure, acute drug-induced

Renal failure, drug metabolism

Renal function nonsteroidal anti-inflammatory drug

Renal insufficiency drug absorption

Renal insufficiency drug distribution

Renal insufficiency drug dosing

Renal insufficiency drug excretion

Renal insufficiency drug metabolism

Renal tubular obstruction, drug-induced

Sequestration of Phosphate Ions Polymeric Drugs for Chronic Renal Failure

Subcutaneous drugs renal disease

Therapeutic drug monitoring renal failure

© 2024 chempedia.info