C-oncogenes

The cellular form of oncogenes (known as c-oncogenes or proto-oncogenes) code for proteins involved in controlling growth and differentiation processes. They only become oncogenes if their sequence has been altered by mutations (see p. 256), deletions, and other processes, or when excessive amounts of the gene products have been produced as a result of overexpression. 

C. Oncogene-Product Antigens 1. HER2 as a Target for mAb-Based Therapies... 

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Retroviridae Types B and C Oncovirus numerous leukemias, including friend. oncogenic of lower animals... 

The leucine zipper motif (see Chapter 3) was first recognized in the amino acid sequences of a yeast transcription factor GCN4, the mammalian transcription factor C/EBP, and three oncogene products, Fos, Jun and Myc, which also act as transcription factors. When the sequences of these proteins are plotted on a helical wheel, a remarkable pattern of leucine residues... 

Thiophene, 2,2-bithiophene, and 2,2, 5, 2"-terthiophene derivatives from Chinese medicinal plants as oncogene signal transduction inhibitors (proteinki-nase C inhibitors) 99PAC1101. 

Giacinti C, Giordano A (2006) RB and cell cycle progression. Oncogene 25 5220-5227... 

Niehrs C (2006) Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25 7469-7481... 

De Virgilio C, Loewith R (2006) Cell growth control little eukaryotes make big contributions. Oncogene 25 6392-6415... 

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Gubits, R.M. Fairhurst, J.L. (1988). c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite. Oncogene 3, 163-168. 

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Basset-S6guin, N., Escot, C., Blanchard, J.M., Kerai, C., Verrier, B., Moin, H. and Guilhou, J.J. (1990). High levels of c-fos proto-oncogene expression in normal human adult skin. J. Invest. Dermatol. 94, 418-422. 

Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998 391(6662) 86-89. 

Many non-receptor tyrosine kinases have been identified as products of retrovirally encoded oncogenes. Non-receptor tyrosine kinases can be divided into two groups transmembrane and cytosolic families. The c-src tyrosine kinase is the prototype of the cytosolic tyrosine kinases. Regions within these non-receptor tyrosine kinases share homology with the Src kinase, known as Src homology 2 and 3 (SH2 and SH3) domains, and mediate protein-protein interactions between the receptor tyrosine kinases and the intracellular targets (reviewed in Cantley et al., 1991 Pawson and Gish, 1992 Mayer and Baltimore, 1993). 

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