Controlled cell growth

This cell line was recently established by Mohan et al. [64], Intensive testing of this cell line regarding its suitability for pharmaceutical purposes has not been performed yet. The cell line is highly interesting, however, because of its controlled cell growth and differentiation capabilities. An integrated DNA section allows cell growth to be switched on or off. Therefore, further examination of this cell line should be of major interest and importance for various pharmaceutical researches. 

Tumor suppressor genes (control cell growth, loss of function, two hits)... 

Drugs aiming to control the same problem may target different sites. For instance, in the treatment of breast cancer, tamoxifen acts to control cell growth by blocking estrogen receptors on the cancer cell, while Arimidex acts to reduce the body s estrogen production. 

The manner in which interferons control cell growth and proliferation is not fully understood. 

Proto-oncogenes can be classified into many different groups, based upon their normal function within cells or based upon sequence homology to other known proteins. Proto-oncogenes have been identified at all levels of the various signal transduction cascades that control cell growth, proliferation and differentiation. 

For other cases, the uptake or internal production of osmotically active solutes can control cell growth, including effects that involve the reversible cell extension caused by changes in internal hydrostatic pressure and are quantitatively described by the volumetric elastic modulus e (Eq. 1.17). For instance, when reversible or elastic changes in volume exist, then (1 )dPidt should be added to the right-hand side of Equation 2.33. Using Equation... 

The nucleic acids, deoxyrribonucleic aciti (DNA) and ribonucleic acid iRNA), are the chemical carriers of a ccU s genetic information. Coded In a cell s DNA is a 3 the inrormation that deterroineti the nature of the cell, controls cell growth and division, and directs bitwynthests of the enzyenes and other pnrt in rc[Pg.1158]

Duncan AC, Weisbuch F, Rouais F, Lazare S, Baquey C. Laser microfabricated model surfaces for controlled cell growth. Biosens Bioelectron 2002 17 413-26. 

Edinger, A.L. (2007) Controlling cell growth and survival through regulated nutrient, transporter expression. The Biochemical Journal, 406 (1), 1—12. 

Normal p53 functions as a tumor suppressor and is a transcription factor that normally participates in the regulation of several genes required to control cell growth, DNA repair, sx d apoptosis (programmed cell death). Normal p53 is a tetramer and it binds to DNA in a sequence-specific manner. One of the p53-regulated genes produces... 

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