C-Src proto-oncogene

Teti, A., Taranta, A., Migliaccio, S., Degiorgi, A., Santandrea, E., Vilanova, L, Faraggiana, T., Chellaiah M., and Hmska, K.A. (1998) Colony Stimulating Factor 1 Induced Osteoclast Spreading Depends on Substrate and Requires the Vitronectin Receptor and the c src Proto-Oncogene. Journal of Bone and Mineral Research 13, 50-58. 

Soriano P, Montgomery C, Geske R, Bradley A. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64 693-702. 

Soriano, P., Montgomery, C., Geske, R., and Bradley, A. (1991) Targeted Disruption of the s src Proto-Oncogene Produces Osteopetrosis in Mice. Cell6A, 693 702. 

Rivero-Lezeano, O. M., Sameshima, J. H., Marcilla, A., and Robbins, K. C. (1994). Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene./. Biol. Chem. 269, 17363-17366. 

The abbreviation used to distinguish protooncogenes from viral oncogenes are the prefixes c-and V-, e.g. c-src and v-src. Proto-oncogenes have usually been identified from their sequence relationship to the viral oncogene, and so they have generally been named after the virus to which they relate. They differ from one another in two ways only... 

Andoniou, C. E., et al.. The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Eyn by enhancing its degradation. Mol Cell Biol, 2000, 20(3), 851-67. 

Sequence analysis of the src gene from viruses and cells revealed small differences between the two. Thus, v-src, refers to the viral form of the gene and c-src to the cellular form. Analysis of many other tumor vimses yielded more than two dozen additional oncogenes. The corresponding proto-oncogenes encode a variety of proteins involved in cell signaling, some of which are identified in Table 23.7. 

Describe the effect of Rous sarcoma virus gene product (v-src) on cell growth and note the relationship of v-src to its cellular counterpart, c-src. Describe the relationship between proto-oncogene and oncogene. 

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