Signal transduction oncogenes

Rapp, U. R. (1991). Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene 6 495-500. 

Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK. 2004. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloprotei-nase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene 23 1845-1853. 

Shimizu S,Eguchi Y, Kamiike W,Waguri S, Uchiyama Y, et al. 1996. Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene 12 2045-50... 

Schechtman, D. and Mochly-Rosen, D. (2001) Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene, 20, 6339-6347. 

Thiophene, 2,2-bithiophene, and 2,2, 5, 2"-terthiophene derivatives from Chinese medicinal plants as oncogene signal transduction inhibitors (proteinki-nase C inhibitors) 99PAC1101. 

LIN J K s, LEE F, HUANG Y T, LiN-SHiAU s Y (1995) Signal transduction and oncogene expression mediated by reactive oxygen species. In Proceedings of the International Symposium on Natural Antioxidants - Molecular Mechanisms and Health Effects. Eds Packer, L, Traber, M G, Xin, W Champaign, I L, USA AOCS Press, 303-19. 

Morrison, D. K., Kaplan, D. R., Rapp, U., and Roberts, T. M. (1988). Signal transduction from membrane to cytoplasm growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc. Natl. Acad. Sci. USA 85 8855-8859. 

Components of Tyrosine Kinase Signal Transduction Cascades Are Discovered as Cellular (or Viral) Oncogenes... 

Ral has attracted much interest in recent years, not least because it was demonstrated to mediate part of Ras function as described above. In contrast to Rap, which rather inhibits Ras signaling, Ral is part of one of the essential Ras-activated pathways. Moreover, it has proved to be acting in parallel with the Raf pathway in cell transformation induced by oncogenic Ras [37, 77]. The case of Ral demonstrates the complexity - and the incomplete knowledge and understanding - of signal transduction. Ral can also be activated by Rap mediated by Rif [103] and, alternatively, by binding of a calcium/calmodulin complex to the Ral C-terminus which obviously does not affect the nucleotide state of Ral [111]. 

Oncogenes that express signals in the signal transduction pathway... 

A feature common to all oncogenes is the fact that they code for proteins involved in signal transduction processes. The genes are designated using three-letter abbreviations that... 

Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (2004) The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Oncogene 23 559-568... 

An exciting development in G-protein-mediated signal transduction research has been the realization that proteins produced by oncogenes (cancer-causing genes) are also GTP-binding proteins. 

---