Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

4- butan-l-amine

Synonyms AI3-24197 1-Aminobutane BRN 0605269 Butan-l-amine 1-Butanamine n-Butylamine CCRIS 4756 EINECS-203-699-2 FEMA No. 3130 Monobutylamine Mono-/3-but-ylamine Norralamine Norvalamine NSC 8029 Tutane UN 1125. [Pg.232]

By applying the two silica sources synthetic approach, perfect crystals of MFI and BEA were produced in the presence of TEA and butan-l-amine as SDA, respectively.11161... [Pg.233]

In a reductive amination/deprotection/Davis-Beirut reaction process, o-nitrobenzaldehydes 147 and 4-(tritylthio)butan-l-amine 148 combined to form a pair of l,3-thiazepino-2H-indazoles 149. Subsequent S-oxidation gave the corresponding sulfones.The oxygen analog 150 was prepared by using 4-aminobutan-l-ol instead of 148 (14JOC6939). [Pg.553]

In the absence of solvent, only syn stereoselectivity and not stereospecificity was observed for the nucleophilic addition of secondary amines such as dimethylamine, diethylamine, piperidine and morpholine to bicyclo[1.1.0]butane-l-carbonitrile. However, similar addition to 3-methylbicy-clo[l. 1.0]butane-l-carbonitrile was more stereoselective.22 However, the addition of sodium methancthiolate to 3-methylbicyclo[1.1.0]butane-l-carbonitrile, methyl bicyclo[l.l.0]butane-1-carboxylate, methyl 3-mcthylbicyclo[1.1.0]butane-l-carboxylate and methyl tricyclo[4.1.0.02 7]-heptane-l-carboxylate also afforded mixtures of cis- and p-rms-cyclobutancs in > 50% yield, with methyl bicyclo[1.1.0]butane-l-carboxylate showing greater anti stereoselectivity.23,24... [Pg.45]

The following are examples of the above procedure. A mixture of diethyl-amine and butan-l-ol may be separated by adding sufficient dilute sulphuric acid to neutralise the base steam distillation will remove the alcohol. The amine can be recovered by adding sodium hydroxide to the residue and repeating the distillation. A mixture of diethyl ketone and acetic acid may be treated with sufficient dilute sodium hydroxide solution to transform the acid into sodium acetate and distilling the aqueous mixture. The ketone will pass over in the steam and the non-volatile, stable salt will remain in the flask. Acidification with dilute sulphuric acid liberates acetic acid, which can be isolated by steam distillation or by extraction. [Pg.1290]

For example, when butan-2-amine is exhaustively methylated, converted to the hydroxide salt, and heated, elimination takes place to form a mixture of but-l-ene and but-2-ene. [Pg.905]

Benzaldehyd 4-[(2-Chlor-ethyl)-methyl-amino]- VII/1, 35 Benzol 2-Acetamino-5-chlor-l,4-dimethyl- V/3, 708 Butan l-(4-Chlor-anilino)-3-oxo-E16d, 759 (En 4 R — NH2) Butansaure 4-Phenyl- -chloramid E5, 1136 (NH -> N —Cl) Carbamidsaure N-Ethyl-N-(4-methyl-phenyl)- -chlorid E4, 49 (OCCl2 4 Amin)... [Pg.748]

Ritter et al. [147-155] have been studying side chain poiyrotaxanes. They synthesized side chain poiyrotaxanes by amide coupling of polymer-carrying carboxylic acid moieties with various semirotaxanes of methylated /l-CD(s) and an axle bearing an amine group at one end [147-154]. These works have been reviewed in an excellent review by Raymo and Stoddard [78]. Ritter et al. [155] reported recently a new type of side chain polyrotaxane. They polymerized inclusion complexes of di(meth)acrylates of butan-l,4-diol and hexan-l,6-diol with a-CD and with methylated /1-CD using a redox initiator system in aqueous media, and characterized the polyrotaxane structure by IR and glass-transition temperature measurements. [Pg.36]

BUTANE-l,2-DIOL (584-03-2) C4H10O2 CH3CHjCH(0H)CH20H Combustible liquid (flash point 194°F/90°C Fire Rating 2). Incompatible with strong oxidizers, strong acids, caustics, aliphatic amines, isocyanates. On small fires, use dry chemical powder (such as Purple-K-Powder), alcohol-resistant foam, water spray, or COj extinguishers. [Pg.163]

To a boiling solution of the preceding allylmethylamide (45 g) in butan-l-ol (500 ml), sodium (46 g in small pieces) is gradually added, and the mixture is then heated under reflux for 1 h. When cold, the solution is treated with water and is distilled into hydrochloric acid until the material that distils is neutral. The distillate is evaporated to dryness in a vacuum, then treated with concentrated sodium hydroxide solution, and the amine is distilled off it has b.p. 65°, wD20 1.4065, and the yield is 48% (6.7 g). [Pg.457]

Fig. 4. Peptide and chemical structure, respectively, of the incretin mimetics exenatide and liraglutide and the DPP inhibitors sitagliptin ((2R)A-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[l,2,4]triazolo[4,3-a]pyrazin-7(8//)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine) and vUdagliptin (l-[[(3-hydroxy-l-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine). (Modified from Drucker and Nanck 2006 [145]). Fig. 4. Peptide and chemical structure, respectively, of the incretin mimetics exenatide and liraglutide and the DPP inhibitors sitagliptin ((2R)A-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[l,2,4]triazolo[4,3-a]pyrazin-7(8//)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine) and vUdagliptin (l-[[(3-hydroxy-l-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine). (Modified from Drucker and Nanck 2006 [145]).
Methylpropane Diethyl(2H)amine Butan-l-ol Butan-2-ol Diethyl ether 2-Methylpropan-1 -ol 2-Methylpropan-2-ol Diethyl sulfoxide... [Pg.33]

The DDP-4 inhibitors are chemically variable and their metabolic pathways are different. Sitagliptin, (2f )-4-oxo-4[3-(tri-fluoromethyl)-5,6-dihydrol[l,2,4]triazolol[4, 3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophe-nyl)butan-2-amine, is primarily eliminated unchanged, 80% being excreted in the... [Pg.894]

N-methyl-N-nitrosamino)-l-(3-pyridyl)butan-l-one Primary amines... [Pg.947]

Up to this point, solely low molecular weight alcohols were used nevertheless, polymeric hydroxyl side chains can also be successfully modified. Khan and coworkers used a hydroxyl-containing poly condensate, which was derived from piperazine and 2,2 -[butane-l,4-diylbi(oxymethanediyl)]dioxirane, as starting polymer (Scheme 8) [14]. Tricyclo[3.3.1.1]decane-l-carbolyl chloride could be attached onto these poly(p-hydroxy amines). By acidic treatment, the backbone amine units were protonated and transformed the main chain into a cationic polymer system. The introduced monoadamantyl moiety could then be selectively linked to p-cyclodextrin units to create graft polymers. [Pg.138]

The most known designer drugs are carphedone 4-chloro-2,5-dimethoxyphenethylamine (2C-C) i 5-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yM-methylpiperazine-l-carboxylate (zopiclone or Z-drug) 4-(N,N-dimethylamino sulfonyl)-7-fluoro-2,l,3-benzoxadiazole (DBD-F) dimethyltryptamine (DMTA) diphenydramine 4-ethyl-2,5-dimethoxyphenethylamine (2C-E) 4-ethylthio-2,5-dimethoxyphenethylamine (2C-T-2) 4-fluoroamphetamine (4-FMP) indan-2-amine 4-iodo-2,5-dimethoxyphenethylamine (2C-I) 1 -(4-iodo-2,5-dimethoxyphenyl)propan-2-amine (DOI) 4-isopropylthio-2,5-dimethyoxyphenethylamine (2C-T-4) meperidine 2-methylamino-l-(3,4-methylenedioxyphenyl)butan-l-one (Bk-MBDB) l-(3,4-methylenedioxybenzyl)piperazine (MDBP) 1 -(3,4-methylenedioxyphenyl)butan-2-amine (BDB) N-methyl-3,4-methylenedioxymethamphetamine (MMDA-2) N-methyl-1 -(3,4-methylenedioxyphenyl)butan-2-amine (HMDMA) N-methyl-l-(3,4-methylenedioxyphenyl)butan-3-amine (HMDMA) methylphenidate 4-methoxymethamphetamine (PMMA) l-(4-methoxyphenyl)piperazine (4-MPP) 2-(6-methyl-2-p-tolylimidazol[l,2-9]pyridine-3-yl)acetamide (zolpidem) normeperidine 4-phenylbutylamine (4-PBA) 3-phenyl-1-peopyTamine (3-PPA) and 2,4,6-trimethoxyamphetamine (TMA-6). [Pg.172]

Kim D, Wang L, Beconi M, Eirmann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio E, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornherry NA, Weber AE. (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro [l,2,4]triazolo[4,3-a]pyrazin-7(8/0-yl]-l-(2,4,5-trifluoro-phenyl)butan-2-amine a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J. Med. Chem. 2005 48 141-151. [Pg.65]

The synthesis of 1-ethoxy-1-butjme has been reported previously, but the preparations have required multistep sequences. Two of the procedures use 1,2-dibromo-l-ethoxy butane which is dehydrohalogenated in two successive steps, first by an amine base and then by either powdered potassium hydroxide or sodium amide no yields are given. The... [Pg.67]

Precursors and Formation. Tobaccos used for commercial products in the U.S.A, contain between 0,5 and 2,7% alkaloids. Nicotine constitutes 85-95% of the total alkaloids (14,26,27). Important minor alkaloids are nornicotine, anatabine, anabasine, cotinine and N -formylnornicotine (Figure 6), Several of these alkaloids are secondary and tertiary amines and, as such, amenable to N-nitrosation. The N-nitrosated alkaloids identified to date in tobacco and tobacco smoke include N -nitrosonornico-tine (NNN), 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone (NNK) and N -nitrosoanatabine (NAT Figure 7). In model experiments, nitrosation of nicotine also yielded 4-(methylnitrosamino)-4-(3-pyridyl)butanal (NNA 28). [Pg.258]

Along another line of work in our group (S,S)-l,4-bis(dimethylamino)-2,3-dimethoxy butane (DDB), which had been used as cosolvent in asymmetric synthesis [113], was tested as a core moiety for a dendritic amine catalyst. The conformationally flexible DDB-core, which has been synthesized in five steps from diethyl tartrate was coupled with different branches to give dendritically expanded diamines 90-92 (molecular weight 3800 Da) [114] (Fig. 32). [Pg.170]


See other pages where 4- butan-l-amine is mentioned: [Pg.1466]    [Pg.344]    [Pg.89]    [Pg.1466]    [Pg.344]    [Pg.89]    [Pg.317]    [Pg.60]    [Pg.419]    [Pg.118]    [Pg.317]    [Pg.383]    [Pg.98]    [Pg.40]    [Pg.4]    [Pg.230]    [Pg.135]    [Pg.165]    [Pg.213]    [Pg.450]    [Pg.515]    [Pg.214]    [Pg.204]    [Pg.195]    [Pg.404]    [Pg.630]    [Pg.237]    [Pg.527]    [Pg.67]   
See also in sourсe #XX -- [ Pg.893 , Pg.924 ]

See also in sourсe #XX -- [ Pg.109 ]




SEARCH



Butan-2-amine

L- butane,

L-Butanal

© 2024 chempedia.info