Amino methylation

Nitraminothiazoles are sufficiently acidic to be alkylated by diazomethane the methyl substituent is introduced on the exocyclic nitrogen (194). When sulfathiazole is methylated with diazomethane in ether, a mixture of ring-methylated and amino-methylated products is obtained, the ratio being 30 70 (85). With anion 31 (R = p-NO CsH4SO -) the ratio becomes 15 85 (195). [Pg.37]

Since pyridazinones are acidic compounds, they undergo IV-hydroxy- and N-amino-methylation. They react also with aromatic aldehydes in the presence of acetic anhydride in the ratio of 2 1 to give the condensation product (73 Scheme 23). [Pg.15]

H-Benzimidazole, 2,2-pentamethylene-reduction, 5, 423 Benzimidazole-2-carbaldehyde oximes, 5, 436 Benzimidazolecarbaldehydes oxidation, 5, 437 Benzimidazole-2-carbamates 5-substituted as anthelmintics, 1, 202 Benzimidazole-1-carboxylic acid, 2-amino-methyl ester reactions, 5, 453... [Pg.538]

Pyrazine, tetrahydro-, 3, 177, 178 Pyrazine, 1,2,3,4-tetrahydro-synthesis, 3, 177 Pyrazine, 2,3,5-tri-t-butyl-synthesis, 3, 185 Pyrazine, 2,3,5-trichloro-nucleophilic substitution, 3, 176 Pyrazine, 2-vinyl-polymers, 1, 290-291 Pyrazine-3-carboxylic acid, 2-amino-methyl ester... [Pg.769]

Racemic /ru -2-(l-naphthylsulfonyl)-7- [4-amino-2-quinaxolinyl)amino-methyl]perhydropyrido[l,2-u]pyrazine was resolved into the optically active enantiomers by means of a Chiralpack column (01MIP20). [Pg.323]

Chemical Name a -[[(1,1-Dlmethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol Common Name Salbutamol a -tert-butylaminomethyl-4-hydroxy-m-xylene-ai,Q 3.diol Structural Formula ciIjOH... [Pg.31]

Methoxy4,5-e2imido Benzoic Acid 1 -AI yl-2-amino-methyl Pyrrolidine Phosphoric Anhydride... [Pg.41]

Chemical Name 3,5-dihydroxy-0 -[ [(p-hydroxy-a -methylphenethyl)amino] methyl] benzyl alcohol hydrobromide... [Pg.629]

The combined liquors, which comprise an aqueous hydrochloric acid solution of 3-amino-methyl-pyridine hydrochloride, are then heated to a temperature of 60° to 65°C, and ethyl nitrite gas is passed into the heated solution. The ethyl nitrite is generated by placing 20 liters of 90% ethyl alcohol in a suitable vessel, diluting with 200 liters of water, and, while stirring, adding to the dilute alcohol 18.3 kg of nitrosyl chloride at the rate of 2.25 kg per hour. (The process using methyl nitrite is carried out by substituting a stoichiometrically equivalent quantity of methyl alcohol for the ethyl alcohol.)... [Pg.1075]

B. Polymeric Urea [Benzene, diethenyl-, polymer with ethenylbenzene, [[[[(1 methylethyl)amino]carbonyt]amino]methyl] deriv.] A 10.0-g. portion of benzylamine polymer beads prepared as in Part A and 125 ml. of tetrahydrofuran (Note 6) are combined in a 300-ml., three-necked, round-bottomed flask equipped with a magnetic stirrer, a dropping funnel, and a condenser fitted with a gas-inlet tube A nitrogen atmosphere is established in the system, and the slurry is stirred while 1.35 g. (0.0159 mole) of isopropyl isocyanate [Propane, 2-isocyanato-] is added. This causes an exothermic reaction, which subsides after about 20 minutes. The mixture is then stirred at room temperature for 22 hours and at reflux for an additional 4 hours. The beads are collected by filtration, washed with 150-ml. portions of tetrahydrofuran (Note 6) and methanol, and dried under reduced pressure over calcium chloride to yield 9.09 g, of the isopropyl urea polymer. [Pg.96]

Carbamic acid, hexyl-, methyl ester, 40 CARBODIIMIDF, POLYMERIC [BENZENE, DIETHENYL-, POLYMER WITH ETHF.NYLBFNZFNE, [[[(<1-METHYLETHYL)IMINO ] METHYLENE] AMINO] METHYL] DERIV.],... [Pg.139]

Isopropylurea-polystyrene [Benzene, di-ethenyl-, polymer with ethenyl-benzene, [[[[(l-methylethyl)amino]-carbonyl]amino]methyl] denv.],96 Isoquinoline, 20... [Pg.141]

CN rranj -2-[[[4-[[(aminoiminomethyl)amino]methyl]cyclohexyl]carbonyl]oxy]benzoic acid phenylmethyl ester... [Pg.193]

RN 3811-25-4 MF C HieiClNO MW 213.71 EINECS 223-291-8 CN 2-chloro-a-[[( 1 -methylethyl)amino]methyl]benzenemethanol... [Pg.531]

CN (R)-a [[[2- 3,4-dimethoxyphenyl)ethyl]amino]methyl]-4-hydroxybenzenemethanol hydrochloride... [Pg.587]

CN 4-amino-3-chloro-a-[[(l,l-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol... [Pg.1203]

CN 5-[[(aminoacetyi)amino]methyl]-1 -[4-chloro-2-(2-chlorobenzoyl)phenyll-A, A/-dimethyl-l //-1,2,4-... [Pg.1814]

CN -[[( l.ciimethylethyl)amino]methyl]-4-hydroxy-l,3-benzenedimethanol sulfate (2 1)... [Pg.1849]

CN ( )-4-hydroxy-a -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-l,3-benzenedimethanol... [Pg.1853]

CN D-glucuronic acid compd. with 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine (1 1)... [Pg.2120]

CN a-[[bis( 1 -methylpropyl)amino]methyl]-1 -[(2-chlorophenyl)methyl]-1 //-pyrrole-2-methanol p-hydroxybenzoate (1 1)... [Pg.2168]

C2HftClN 689-98-5) see Fluvoxamine 2-chloroethylamine hydrochloride (C2H7CI2N 870-24-6) see Ifosfamide a-[[(2-chloroetbyl)amino]methyl]benzenemethanol hydrochloride... [Pg.2328]

C14H21NO2 103756-12-3) see Phenindamine methyl 4-[[iV-(l-iminopentyl)amino]methyl]benzoate (C14H20N2O2 /9S065-S0-4) see Eprosartan... [Pg.2416]

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