5- Methyl-6-phenyl

Besides the well-known lower basicity of ethanol, these data illustrate the greater acidity of benzoxazolium compared with benzothiazolium. The relative pK. values of the quaternary salts obtained in acetonitrile when treated with tetrabutylammonium hydroxide are 18.3 and 17.6, respectively (25). Those of 2-methyl 4-phenyl thiazolium and 2.4-dimethyl thiazolium are 20.5 and 21.8 under the same conditions (25). 

An isotopic effect (H or D) has been demonstrated when starting from 2-methyl-4-phenylthiazole or from 2-methyl-4-phenyl-5-D-thiazole (224) in the dimerisation reaction. 

Some studies on the quatemization of arylthiazoles have been published, among them the quatemization of 2-methyI-4-phenyl thiazole in various solvents (263). The order of reactivity is the following 2-methyl-4-phenyl > 2-methyI-4-(3-nitrophenyl) > 2-methyl-4-(2-chlorophenyl) > 2-methyl-4-(4-nitrophenyl). Introduction of a phenyl group in the... 

N-Unsubstituted 1,2,3-triazoles are methylated mainly in the 1-position with methyl iodide and silver or thallium salts, but mainly in the 2-position by diazomethane. There is also some steric control. For example, 4-phenyl-l,2,3-triazole with dimethyl sulfate gives the 2-methyl-4-phenyl (38%) and l-methyl-4-phenyl isomers (62%), but none of the more hindered 1-methyl-5-phenyltriazole (74AHC(16)33). JV-Unsubstituted 1,2,4-triazoles are generally alkylated at N-1. 

Imidazole, 1 -methyl-5-nitro-2-styryl-ozonolysis, 5, 437 Imidazole, l-methyl-2-phenyl- C NMR, 5, 354 Imidazole, l-methyl-4-phenyl- C NMR, 5, 355 Imidazole, 2-methyl-4-phenyl-acylation, 5, 402... 

Pteridine, 2-methyl-4-phenyl-stnicture, 3, 266 Pteridine, 4-methyl-2-phenyl-stnicture, 3, 266 Pteridine, 7-methyl-2-phenyl-stnicture, 3, 266 Pteridine, 7-methyl-4-phenyl-stnicture, 3, 266 Pteridine, 2-methylthio-stnicture, 3, 273 Pteridine, 4-methylthio-stnicture, 3, 273... 

Pyrimidine, 2-methyl-4-phenoxy-synthesis, 3, 120 Pyrimidine, 2-methyl-4-phenyl-syntfaesis, 3, 109 Pyrimidine, 4-methyl-2-pfaenyl-... 

A solution of N-(2-aminobenzvl)-1-phenyl-2-metKylaminoethanol-1 was prepared by the reaction of a-bromo-acetophenone and (2-nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickei on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. Dy extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-iso-quinoline. The base is reacted with maleic acid to give the maleate melting point of the maleate 199° to 201°C (from ethanol). 

Methyl-4-phenyl-2Z/-2,3-benzodiazepin-l(5//)-one (15a) is brominated by /V-broinosuccin-imide in 10 % yield or by trimethylphenylammonium perbromide in 40 % yield to give 5-bromo-2-methyl-4-phenyl-2//-2,3-benzodiazepin-l(5//)-one (16).137... 

Reduction of 2-methyl-4-phenyl-3//-pyrido[l,2-Z)]pyridazin-3-one (44) with NaBH4 in ethanol afforded the 5,6,7,8-tetrahydro derivative [76JCS(CC)275 78JOC2892],... 

Some furans with conjugating 2- or 3-substituents show abnormal behaviour during oxidation in methanol. Only one methoxy group is introduced after which loss of a proton restores the furan to substituent conjugation. This behaviour is shown by 2- and 3-phenyifurans and by 2-(then-2-yl)furan. 2-Methyl-4-phenyl-... 

Dipolar cycloaddition of 4-arylmethyleneisoxazol-5-ones 794 and 2-methyl-4-phenyl-5(4//)-oxazolone 795 leads to pyrrole-3-carboxyhc acids that have been isolated as hydroxamates 796. The authors carried out this cycloaddition-nitrile oxide addition as a one-pot reaction (Scheme 7.243). ... 

Amino-carboxy-methyl )-2-methyl-. [bzw. -2,4-dimethyl-... bzw. 2-methyl-4-phenyl-...]-/, 2-oxazol (X = H, CH CSHS)... 

CoClPjC H, Cobalt, chlorotris-(triphenylphosphine)-, 26 190 CoN203C15H9, Cobalt, tricarbonyl[2-(phenylazo)phenyl-C, A ]-, 26 176 CoO PC3jHm, Cobalt, (V 2-propynoate) (triphenylphosphine)-, 26 192 CoC PCmH, Cobalt, (Ty -cyclopentadienyl) [ 1,3-bis(methoxycarbonyl)-2-methyl-4-phenyl-l, 3-butadiene-1,4-diyl]-(triphenylphosphine)-, 26 197... 

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