Breast, lung, bladder, pancreas

Sainz and colleagues studied the presence of Nap-A in 967 lung neoplasms. The authors found that less than 5% of carcinomas of the bladder, pancreas, breast, liver, biliary tract, colon, ovary, uterus, lung squamous cell carcinoma, and lung small cell carcinoma were positive for Nap-A and that 74% of lung adenocarcinomas were positive for Nap-A versus 63% positive for... 

More than half of the people diagnosed with cancer each year have a mutant form of p53 in their cancers. Different forms of cancer have been shown to result from different mutations in the protein, and the list of cancer types associated with mutant p53 includes cancers of most of the body parts brain, breast, bladder, cervix, colon, liver, lung, ovary, pancreas, prostate, skin, stomach, and so on. 

An imcontroUed increase in the concentration and activity of the cyclins D1 and CDK4 can lead to unprogrammed phosphorylation of the pRb protein. Overexpression of cycUn D1 or CDK4 has been found in various tumors of the bladder, breast, pancreas and the lungs (Weintraub, 1995). 

Two types of epidemiological relationships have been found in two different populations. Both relationships were inverse to selenium bioavailability and paralleled the results from animal studies. In one type of study, selenium bioavailability has been inversely related to human cancer mortality in American cities and states (14-15). Schrauzer et.al. correlated the age-adjusted mortality from cancer at 17 major body sites with the apparent dietary selenium intakes estimated from food consumption data in 27 countries (16). Significant inverse correlations were observed for cancers of the large intestine, rectum, prostate, breast, ovary, lung, and leukemia. In addition, weaker inverse associations were found for cancers of the pancreas, skin, and bladder. 

Cadmium is widely used in pigments, electroplating processes, and alkaline batteries. It is also a component of cigarette smoke. It has long been known to cause renal cancer in humans, I35l and is also associated with cancer of the lung, pancreas, breast, prostate, and bladder. I36l... 

D1 or CDK4 has been found in various tumors of the bladder, breast, pancreas, and lungs. 

Primary adenocarcinomas of the lung are typically CK7-F, CK20-, and CEA-f, whereas colorectal carcinomas are CK7-, CK20-F, and CEA-i- ductal and lobular breast carcinomas are CK7-f, CK20-, and often CEA-I- and ovarian carcinomas are CK7-I-, CK20 , and CEA-.121,125-129,224-227 Neoplasms that typically are strongly positive for most CEA antibodies include adenocarcinomas of the lung, colon, stomach, biliary tree, pancreas, urinary bladder, endocervix, paranasal... 

TTF-1. Also, 11% of lung adenocarcinomas detected by Nap-A were missed by TTF-1 staining. The authors concluded that Napsin A was a valuable marker for detecting lung adenocarcinomas versus other adenocarcinomas such as those from the breast, colon, biliary tract, pancreas, urinary bladder, and ovary. It was less useful in distinguishing primary pulmonary adenocarcinomas from thyroid carcinomas and renal carcinomas. 

Lung Stomach Breast Pancreas Colon Bladder g... 

The annual incidence rates (crude and age-standardized) and the numbers of new cases of cancers at 18 major sites in 1985 were estimated for 24 areas of the world [1] the data for the IS commonest cancers in men and women are summarized in Table 16.1. Lung cancer is the commonest cancer in men and the incidence rates are increasing in both developed and developing countries it is now the 3rd commonest cancer among women in North America and the 5th commonest worldwide. Breast cancer is still the commonest cancer in women, followed by cancer of the cervix. Wruldwide, cancers of the colon and rectum are the 3rd commonest cancers in both sexes. Canco s of the urinary bladder and pancreas are more common in developed than in developing countries. The incidence of lymphoma appears to be increasing. 

Adenocarcinoma of breast, colon, biliary tract, pancreas, lung, ovary, skin papillary transitional cell carcinoma of bladder, anaplastic large cell lymphoma, diffuse large B-cell lymphoma... 

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