Bowel cancer

HAGUE A, MANNING A M, HANLON K A, HUSCHTSCHA L I, HART D, PARASKEVA C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway impUcations for the possible role of dietary fibre in the prevention of large-bowel cancer. /ni J Cancer. 55 498-505. 

MCINTYRE A, GIBSON p R YOUNG G p (1993) Butyrate production from dietary fiber and protection against large bowel cancer in a rat model. Gut 34 386-91. 

Prevention of colon and large bowel cancer (Cummings 1992). 

Baron, J. A., Gerhardsson de Verdier, M., Ekbom, A., Coffee, tea, tobacco, and cancer of the large bowel, Cancer Epidemiol Biomed Prev, 3, 565, 1994. 

The most surprising observations on Table II are the lack of a clear relationship between meat use and risk of fatal cancers of the large bowel and breast. Evidence from several other studies suggests that a direct positive association should be evident (10). However, data from a growing number of recent studies are not consistent with an association between meat use and risk of large bowel cancer or breast cancer (17-19). Meat use is also unrelated to all types of cancer combined. 

Unfortunately, the questionnaire did not distinguish between caffeinated versus decaffeinated coffee or instant versus brewed coffee. Positive associations with coffee use are seen for fatal large bowel cancer in both sexes, fatal coronary disease in males only, and possibly for all causes of death in males only. Both sexes were combined for large bowel cancer because the degree of association was essentially equivalent when examined separately for... 

Compared to the general population, Adventists have an exceptionally low risk of fatal lung cancer and other diseases which are strongly related to cigarette or alcohol use. They also appear to have a marked reduction in risk of death from large bowel cancer, coronary disease, stroke, diabetes, and nontraffic accidents. 

Coffee use among Adventists is moderately related to risk of death from large bowel cancer in both sexes, as well as coronary disease and all causes in males. 

J. S. Crowther, B. S. Drasar, M. J. Hill, R. Maclennan, D. Magnin, S. Peach and C. H. Teoh-chan, Faecal steroids and bacteria and large bowel cancer in Hong Kong by socio-economic groups, Br. J. Cancer, 1976, 34(2), 191. 

B. S. Reddy, A. R. Hedges, K. Laakso and E. L. Wynder, Metabolic epidemiology of large bowel cancer fecal bulk and constituents of high-risk North American and low-risk Finnish population. Cancer, 1978, 42(6), 2832. 

O. M. Jensen, R. MacLennan and J. Wahrendorf, Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland, Nutr. Cancer, 1982, 4(1), 5. 

Rosenberg L, Palmer J, Zauber A, et al. A hypothesis non-steroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst 1991 83 355-358. 

Cancer. Studies found no relationship between endogenous p-cresol levels in the urine and the occurrence of large bowel cancer (Bone et al. 1976) or bladder cancer (Renwick et al. 1988) in humans. There are no data available regarding the carcinogenicity of exogenous cresols in humans. No cancer bioassays have been conducted in animals, but the results of a promotion study in mice suggested that cresols can be cancer promoters. Cresols have some ability to interact with mammalian DNA in vitro, but it is impossible to assess the potential hazard to humans without more information. 

Bone E, Tamm A, Hill M. 1976. The production of urinary phenols by gut bacteria and their possible role in the causation of large bowel cancer. Am J Clin Nutr 29 1448-1454. 

Fibre drinks, containing both soluble and insoluble fibres (non-starch polysaccharides). These drinks add bulk to the diet and increase stool weight (a low stool weight is associated with an increased risk of bowel cancer and gall stones). Fibre also binds cholesterol (a risk factor for heart disease), thus reducing its adsorption from the intestine. To support a claim, the quantity of drink consumed in a day must provide at least 3 g of fibre, i.e. one-sixth of the recommended daily allowance of 18 g. 

This work was supported in part by the United States Public Health Service Grant CA-14905 from the National Cancer Institute through the National Large Bowel Cancer Project, and by the Veterans Administration Medical Research Service. 

Stanish, W. Mahoney, A. Sorenson, A. Avion, E. In "1983 Workshop A Decade of Achievements and Challenges in Large Bowel Carcinogenesis". National Large Bowel Cancer Project, Houston, Tx. p. 3, 1983. 

What are the typical signs and symptoms of bowel cancer that should alert a healthcare professional to refer to a specialist ... 

Dajani, E, Z, (1993), w-3 fatty acids and bowel cancer. Gastmentemiogy 104, 1239-1240,... 

We will focus on cancer of the large bowel, rather than on revealing fragments of information on all of the major types of cancers. The incidence of cancer of the large bowel (colon and rectum) in the United States is 136,000 cases per year, while the incidence of death from colorectal cancer is about 55,000 per year (Lewis, 1996). Large bowel cancer develops with the appearance of a distinct number of genetic mutations, as do all other types of cancers. In the case of cancers of colorectal cancer, the steps tend to follow this progression ... 

Large bowel, cancer of, see Colorectal cancer Largo intestine, dietary fiber and, 144-147 Laxative abuse, 723... 

Chronic administration increases the incidence of cholesterolic gallstones twofold. It also causes a small increase in thromboembolic phenomenon, pulmonary embolism, intermittent claudication, and angina pectoris. The drug may increase the incidence of bowel cancer. Overall, clofibrate cannot be classified as carcinogenic in humans. 

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