Blood brain barrier disrupting

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Warach S, Latour LL. Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke 2004 35 2659-2661. [Pg.37]

Gasche, Y., Copin, J. C., Sugawara, T., Fujimura, M. and Chan, P. H. Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. /. Cereb. Blood Plow Metab. 21 1393-1400,2001. [Pg.571]

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Neuwelt, E.A., et al. 1991. Primary CNS lymphoma treated with osmotic blood-brain barrier disruption Prolonged survival and preservation of cognitive function. J Clin Oncol 9 1580. [Pg.612]

Hynynen, K., et al. 2005. Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage 24 12. [Pg.613]

Temporal Profile of Blood-Brain Barrier Disruption 141... [Pg.133]

Runge VM, Price AC, Wehr CJ, Atkinson JB, Tweedle MF (1985) Contrast enhanced MRI. Evaluation of a canine model of osmotic blood-brain barrier disruption. Invest Radiol 20 830-844... [Pg.147]

Greenlee JE, Burns JB, Rose JW, Jaeckle KA, Clawson S. Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption. Acta Neuropathol (Berl) 1995 89(4) 341-345. [Pg.182]

KaribeH.,ZarowG. J., GrahamS. H., and WeinsteinP.R. (1994) Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 14, 620-627. [Pg.60]

Jiang J. Y., Lyeth B. G., Kapasi M. Z., Jenkins L. W., and Povlishock J. T. (1992) Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat. Acta Neuropathol. 84, 495-500. [Pg.77]

Povlishock J. T. and Lyeth B. G. (1989) Traumatically induced blood-brain barrier disruption a conduit for the passage of circulating excitatory neurotransmitters. Soc. Neurosci. Abstr. 15, 1113 (Abstr). [Pg.140]

The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood-brain barrier (BBB). Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery. [Pg.175]

Kinoshita, M., McDannold, N., Jolesz, F.A., and Hynynen, K. (2006) Noninva-sive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc. Natl. Acad. Sci. U.S.A. 103,11719-11723. [Pg.186]

McDannold, N., Vykhodtseva, N., and Hynynen, K. (2007) Use of ultrasound pulses combined with definity for targeted blood-brain barrier disruption a feasibility study. Ultrasound Med. Biol. 33,584-590. [Pg.186]

Chi OZ, Hunter C, Liu X, Weiss HR (2007) Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia. Exp Neurol 204 283-287 Chu K, Jeong SW, Jung KH, Han SY, Lee ST, Kim M, Roh JK (2004) Celecoxib induces fimctional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. J Cereb Blood Flow Metab 24 926-933... [Pg.157]

Liu W, Hendren J, Qin XJ, Shen J, Liu KJ (2009) Normobaiic hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem 108 811-820... [Pg.162]

Paul R, Lorenzl S, Koedel U, Sporer B, Vogel U, Frosch M, Pfister HW (1998) Matrix metallo-proteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Aim Neurol 44 592-600... [Pg.164]

Lee HJ, Zhang Y, Pardridge WM. Blood-brain barrier disruption following the internal carotid arterial perfusion of alkyl glycerols. J Drug Target 2002 10 463-7. [Pg.222]

B. Blood-Brain Barrier Disruption Following Acute Insults... [Pg.133]

FIGURE 4.3 Blood-brain barrier disruption as revealed by computerized tomography A. Normal CT scan, before and after injection of the enhancement material, Omnipaque . Note the enhancement (hyperdense white) in brain arteries and vein sinuses (wide arrows) without penetration into the brain parenchyma. B. A case of multiple brain metastases in a 41-year-old female with a history of breast cancer. Following injection of Omnipaque , several round white regions appear, reflecting focal BBB disruption in the regions harboring tumors (thin arrows). [Pg.144]

V. CONDITIONS INDUCING BLOOD-BRAIN BARRIER DISRUPTION... [Pg.146]

Disruption of the BBB was reported in MS patients examined by contrast-enhanced MRI. " Blood-brain barrier disruption in MS patients was suggested to be the initial event in the development of the brain lesions that are characteristic of the advanced stages of this disease. It correlates with the severity of symptoms, and an earlier age of the disease onset. Another pathological condition in which BBB breakdown was demonstrated is epilepsy. Disruption was demonstrated by computerized tomography (CT) in a patient following generalized seizure and by Evans blue penetration in a rat model of pentylentetrazol-induced seizures. ... [Pg.146]

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