Focal brain ischemia

Latour LL, Kang DW, Ezzeddine MA, Chalela JA, Warach S. Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol 2004 56 468 77. [Pg.37]

Warach S, Latour LL. Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke 2004 35 2659-2661. [Pg.37]

Schmidt-Kastner R, Zhang B, Belayev L, Khoutorova L, Amin R, et al. 2002. DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat. Brain Res Mol Brain Res 108 81. [Pg.407]

Zhang B., Tanaka J., Yang L., Yang L., Sakanaka M., Hata R., Maeda N., and Mitsuda N. (2004). Protective effect of vitamin E against focal brain ischemia and neuronal death through induction oftarget genes of hypoxia-inducible factor-1. Neuroscience 126 433 440. [Pg.240]

Here we investigate the neuroprotective potential of BEO in vivo by using an experimental model of focal brain ischemia in rats. Moreover, we evaluate whether neuroprotection is associated with altered levels of excitatory neurotransmitters and with a modulation of PI3-K/Akt pathway in the ischemic cortex. Our results indicate that BEO indeed protects against ischemic injury in an in vivo model of permanent focal brain ischemia in rat and that neuroprotection is associated with reduced excitatory amino acid efflux induced by MCAo in the ischemic cortex and elevation ofp-Akt and phospho-GSK-3/3 (p-GSK-3/3) levels in the ischemic penumbra. A preliminary account of this in vivo study has been communicated to the British Pharmacologic Society (Morrone et al., 2006). [Pg.391]

Li F, Silva MD, Liu KF, Helmer KG, Omae T, Fenstermacher JD, Sotak CH, Fisher M (2000) Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats. Ann Neurol 48 236-244... [Pg.38]

Blood flow regulation systems are disturbed in acute focal brain ischemia when an increase in blood pressure, but not of arterial PaC02, causes a rise of CBF (Shima et al. 1983). Disturbances of flow regulation are not confined to the ischemic focus... [Pg.46]

Dirnagl U, Pulsinelli W (1990) Autoregulation of cerebral blood flow in experimental focal brain ischemia. J Cereb Blood Flow Metab 10 327-336... [Pg.68]

In the early stages of focal brain ischemia, CT can demonstrate areas of hypoattenuation in the brain tissue that correspond to acute severe ischemia (von Kummer et al. 2001). It may be more difficult to detect diffuse pathology (Fig. 16.1). While early changes such as hypoattenuation and sulcal efface-ment may be detected by experts, the inexperienced interpreter may miss them. The sensitivity of CT... [Pg.240]

Immediately after the onset of focal brain ischemia, oxygen and glucose deprivation result in loss of adenosine triphosphate (ATP), loss of maintenance of normal ion channels and neuronal depolarization (Wahlgren and Ahmed, 2004) as evidenced by calcium and sodium influx into the cells. [Pg.431]

Zhang Y Pardridge WM (2001b) Neuroprotecdon in transient focal brain ischemia after delayed intravenous administradon of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targedng system. Stroke 32 1378—1384. [Pg.708]

Y. Okada, B. R. Copeland, E. Mori, M. M. Tung, W. S. Thomas, and G. J. del Zoppo, P-Selectin and Intercellular Adhesion Molecule-1 Expression after Focal Brain Ischemia and Reperfusion. Stroke. 25(1994)202-211. [Pg.200]

Sorensen JC, Mattsson B, Andreasen A, Johansson BB. Rapid disappearance of zinc positive terminals in focal brain ischemia. Brain Res. 1998 812 265-269... [Pg.16]

Tagaya M, Haring H P, Stuiver I, et al. (2001). Rapid loss of microvascular integrin expression during focal brain ischemia reflects neuron injury. J. Cereb. Blood Flow. Metab. 21 835-846. [Pg.571]

Tagaya M, Liu K F, Copeland B, et al. (1997). DNA scission after focal brain ischemia temporal differences in two species. Stroke. 28 1245-1254. [Pg.571]

Gisselsson, L., Smith, M.L., and Siesjo, B.K. (1999) Hyperglycemia and focal brain ischemia. J. Cereb. Blood Flow Metab., 19 288-297. [Pg.79]

Zhao, L.R., Spellman, S., Kim, J., Duan, W.M., McCarthy, J.B., Low, W.C., 2005. Synthetic fibronectin peptide exerts nenroprotective effects on transient focal brain ischemia in rats. Brain Res. 1054,1-8. [Pg.118]

Zhang YG, Liu TP. Infleuences of ginsenosides Rbl and Rgl on reversible focal brain ischemia in rats. Chung Kuo Yao Li Hsueh Pao 1996 17 44—48. [Pg.235]

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