Biomacromolecules

Liquid chromatography is complementary to gas chromatography because samples that cannot be easily handled in the gas phase, such as nonvolatile compounds or thermally unstable ones, eg, many natural products, pharmaceuticals, and biomacromolecules, are separable by partitioning between a Hquid mobile phase and a stationary phase, often at ambient temperature. Developments in the technology of Ic have led to many separations, done by gc in the past, to be carried out by Hquid chromatography. 

INVESTIGATION OF PEROXID OXIDATION PROCESSES OF BIOMACROMOLECULES LEADING TO CHEMILUMINESCENCE... 

Peroxide oxidation processes in human organism are one of based phenomena that is responsible for homeostasis. For this reason development and investigation of interaction mechanism between different biomacromolecules and lipids peroxide are important for forming complete picture of functioning of human being as biological system. 

T Ichiye, RB Yelle, JB Koerner, PD Swartz, BW Beck. Molecular dynamics simulation studies of electron transfer properties of Ee-S proteins. Biomacromolecules Erom 3-D Structure to Applications. Hanford Symposium on Health and the Environment 34, Pasco, WA, 1995, pp 203-213. 

The described bioaffinity separations demonstrate that polyacrylamide spacers aid the selective binding of highly complex and delicate biomacromolecules and their associates. Moreover, these solutes remain biologically active after desorption probably due to the high inertness and flexibility of the surrounding polymer chains fixed on the solid support. The unbound parts of serum usually show no loss of the activities of their constituents. Thus we evaluate the surface of inorganic supports coated with chemisorbed iV-hydroxyethyl polyacrylamide and its derivatives as being biocompatible. 

PicoutDR, Ross-Murphy SB, Errington N, Harding SE (2003) Biomacromolecules 4 799... 

Picout DR, Ross-Murphy SB, Jumel K, Harding SE (2002) Biomacromolecules 3 761... 

Noishiki Y, Takami H, Nishiyama Y, Wada M, Okada S, Kuga S (2003) Biomacromolecules 4 896... 

Morimoto M, Saimoto H, Usui H, Okamoto Y, Minami S, Shigemasa Y (2001) Biomacromolecules 2 1133... 

Renard, D. Lavenant-Gourgeon, L. Ralet, M. Sanchez, C. (2006). Acacia Senegal Gum Continuum of Molecular Species Differing by Their Protein to Sugar Ratio, Molecular Weight, and Charges. Biomacromolecules, Vol.7, No.9, (Augudt 2006), pp. 2637-2649, ISSN 1525-7797. 

The swollen specific volume n p (cm /g) is defined when an anhydrous biomacromolecules essentially expand in suspended or dissolved in solution because of solvent association, and... 

Meyer M., Morgenstern B. 2003. Characterization of Gelatine and Acid Soluble Collagen by Size Exclusion Chromatography Coupled with Multi Angle Light Scattering (SEC-MALS). Biomacromolecules 4,1727-1732. 

Ortega, A. Garcia de la Torre, J. 2007. Equivalent Radii and Ratios of Radii from Solution Properties as Indicators of Macromolecular Conformation, Shape, and Flexibility. Biomacromolecules 8, 2464-2475. 

Papadopoulos, P. etal. Nanodomain-induced chain folding poly(gamma-benzyl-L-glutamate)-b-polyglycine diblock copolymers. Biomacromolecules, 6, 2352, 2005. 

Puskas, J.E. and Chen, Y. Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement. Biomacromolecules, 5, 1141, 2004 GAK-GV, 7, 455 8, 526, 2004 (German). 

El Fray, M., Prowans, P., Puskas, J.E., and Altstadt, V. Biocompatibility and fatigue properties of polystyrene-polyisobutylene-polystyrene, an emerging thermoplastic elastomeric biomaterial. Biomacromolecules, 7, 844-850, 2006. 

Noda I, Green PR, Satkowski MM, and Schechtman LA. Preparation and properties of a novel class of polyhydroxyaUcanoate copolymers. Biomacromolecules, 2005, 6, 580-586. 

Thomas V, Kumari TV, and Jayabalan M. In vitro studies on the effect of physical cross-linking on the biological performance of aliphatic polyfurethane urea) for blood contact applications. Biomacromolecules, 2001, 2, 588-596. 

Yang M and Santerre JP. Utihzation of quinolone drugs as monomers Characterization of the synthesis reaction products for poly(norfloxacin diisocyanatododecane polycaprolactone). Biomacromolecules, 2001, 2, 134-141. 

Anurima S, Nicholas RK, Swaminathan S, Lakshmi SN, Jacqueline LS, Paul WB, Cato TL, and Harry RA. Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes. Biomacromolecules, 2006, 7, 914-918. 

Barrett EW, Phelps MVB, Silva RJ, Gaumond RP, and Allcock HR. Patterning poly(organophospha-zenes) for selective cell adhesion applications. Biomacromolecules, 2005, 6, 1689-1697. 

Alternatively, one interesting drug delivery technique exploits the active transport of certain naturally-occurring and relatively small biomacromolecules across the cellular membrane. For instance, the nuclear transcription activator protein (Tat) from HIV type 1 (HlV-1) is a 101-amino acid protein that must interact with a 59-base RNA stem-loop structure, called the traus-activation region (Tar) at the 5 end of all nascent HlV-1 mRNA molecules, in order for the vims to replicate. HIV-Tat is actively transported across the cell membrane, and localizes to the nucleus [28]. It has been found that the arginine-rich Tar-binding region of the Tat protein, residues 49-57 (Tat+9 57), is primarily responsible for this translocation activity [29]. 

Aliferis T, latrou H, Hadjichristidis N (2004) Living polypeptides. Biomacromolecules 5 1653-1656... 

Tang HY, Zhang DH (2010) General route toward side-chain-fimctionalized alpha-helical polypeptides. Biomacromolecules 11 1585-1592... 

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