Biodegradable delivery systems

Various antimalarial drugs have been studied in biodegradable delivery systems. Wise (89) reported the use of a lactide/glycolide copolymer and also poly(L-lactic acid) for release of drugs such as quinazoline and sulfadiazine. Although in vitro data and experiments in mice were somewhat encouraging, these early formulations failed to reach significant clinical status. 

Pitt, C. G., and Schindler, A., Capronor A biodegradable delivery system for levonorgestrel, in Long-Acting Contraceptive Delivery Systems (G. I. Zatuchni, A. Goldsmith, J. D. Shelton, and J. J. Sciarra, eds.). Harper and Row, Philadelphia, 1984, pp. 48-63. 

A biodegradable delivery system using subcutaneous implants of fused pellets made from norethisterone and pure cholesterol has been tested (12). 

Sidman, K.R. Schwope, A.D. Steber, W.D. Rudolph, S.E. Use of synthetic polypeptides in the preparation of biodegradable delivery systems for narcotic antagonists. NIDA Research Monograph 1981, 28, 214—231. 

Nanogels have also been utilized for the delivery of local anesthetic drugs. Yin et al. designed a biodegradable delivery system where lidocaine was encapsulated into poly(e-caprolactone)-poly(ethylene glycol)-poly(e-caprolactone) (PCL-PEG-PCL or PCEC) nanoparticles. s Carriers... 

Furr, B. J. A., and Hutchinson, F. G, 1992, A biodegradable delivery system for peptides Preclinical experience with the gonadotrophin-releasing hormone agonist, Zoladex , J. ControlledReleasell 117-128. 

Yewey, G. L., Duysen, E. G., Southard, J. L., and Dum, R L., 1993, Controlled release of growth factors from a biodegradable delivery system, in Portland Bone Symposium 1993 (J. Hollinger and A. E. Seyfer, eds.), Oregon Health Sciences University, Portland, pp. 453 54. 

AUcock HR (1990) In Chasin M, hanger R (eds) Biodegradable polymers as drug delivery systems. Dekker, New York, chap 5, p 163... 

Cha, Y., and Pitt, C. C., A one-week subdermal delivery system for L-methadone based in biodegradable microspheres,... 

Pitt, C. G., Gratzl, M. M., Jeffcoat, A. R., Zweidinger, R., and Schindler, A., Sustained drug delivery systems. II. Factors affecting release rates from poly( e-caprolactone) and related biodegradable polyesters, J. Pharm. Sci.. 68, 1534-1538, 1979. 

Pitt, C. G., Marks, T. A., and Schindler, A., Biodegradable drug delivery systems based on aliphatic polyesters application to contraceptives and narcotic antagonists, in Controlled Release of Bioactive Materials (R. Baker, ed.). Academic Press, New York, 1980, pp. 19-43. 

Kohn, J., and Langer, R., Non-peptide poly(amino acids) for biodegradable drug delivery systems, in Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials (N. A. Peppas and R. J. Haluska, eds.). Controlled Release Society, Lincolnshire, IL, 1985, pp. 51-52. 

Since the purpose of this book is to describe applications of biodegradable polymers to drug delivery systems, particularly from the perspective of the materials employed, the approach taken in this chapter has been to focus on the natural biodegradable polymers which have been used most extensively as matrices for the delivery of drugs. Consideration was also given to the fact that collagen has not been the subject of any recent reviews. 

Kohn, J. In Biodegradable Polymers as Drug Delivery Systems Chasin M. Langer, R., Eds. Drugs and the Pharmaceutical Sciences Marcel Dekker, Inc., New York, NY, 1990, Vol. 45, pp. 195-229. 

---