Polymer polypeptide

Keywords Drug delivery Encapsulation Polymer Polypeptide Vesicle... 

Polymer Polypeptide Polysaccharide Very long chains of like units, as in polythene . Chains of amino acids joined together with peptide bonds. Chains of sugar-like compounds as in cellulose (see monosaccharide). 

Proteins are linear polymers (polypeptides) with the amino acids as the monomer units. The molecular weight of a protein is typically in the range of 10000-100000 for a single chain. Higher molecular weights occur by the association of several protein chains. There are 20 amino acids commonly associated in proteins. The general formula of an amino acid is as follows ... 

Finally we note that, apart from double-tailed surfactant molecules, vesicular aggregates can also be formed from a number of other building blocks, including nonionic amphiphiles to form niosomes, single-tailed surfactants and complex (co)polymers, polypeptides, and dendrimers. In this chapter we restrict our discussion to encapsulation processes by vesicles formed from synthetic surfactants and phospholipids. 

Proteins are amino acid polymers (polypeptides) with distinctive charge and shape characteristics that can change depending on their microenvironment. Selection of a specific CE analytical system for a specific protein application depends on the objectives of the separation and how the protein or proteins of interest behave in any particular analytical system. The specificity and selectivity of any CE analytical system depends in part on the physical and chemical properties of the protein itself. 

This extra element of cross-linking of the polymer (polypeptide) chains by metal ions—in practice, chiefly chromium(III) giving chrome-leather —underlies the utility of leather tanning. It is the formatin of coordinated chromium(III) that gives the tan. 

Enzyme-responsive polymer conjugates are typically block polymers of an artihdal polymer and a polypeptide. Three strategies have been explored to prepare polymer-polypeptide conjugates. Firstly, the artificial polymer (e.g., PEG/PEO) can be immobilised on a solid support and terminated with an amine group (Fig. 6.11). This makes direct SPPS of the polypeptide... 

Rubatat, L., Kong, X., Jenekhe, S.A. et al. (2008) Self-assembly of polypeptide/it-conjugated polymer/polypeptide triblock copolymers in rod-rod-iod and coil-iod-coil conformations. Macromolecules, 41,1846-1852. 

Polymer-polypeptide hybrid block copolymers are able to self-assemble either in bulk (microphase separation) or in selective solvents (micellization), like conventional block copolymers, and in addition are organized within the microphases into a-helix or j5-sheet... 

Table 13.1 List of synthetic polymers, polypeptides, nucleotides, and polysaccharides typically used for fabrication of capsules...

Interaction Synthetic polymers Polypeptides, DNA, proteins Polysaccharides... 

Changes in area/molecule values calculated at 10, 20, 30, 40 and 50 mN/m surface pressure from compression isotherms of DPPC and DPPC/PG (95/5, 80/20 mol/mol) monolayers formed on polymer polypeptide solution and buffer subphase. (AA=Apoiymer-Abuffer)-... 

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