Biodegradability drug delivery systems

Pitt, C. G., Marks, T. A., and Schindler, A., Biodegradable drug delivery systems based on aliphatic polyesters application to contraceptives and narcotic antagonists, in Controlled Release of Bioactive Materials (R. Baker, ed.). Academic Press, New York, 1980, pp. 19-43. 

Kohn, J., and Langer, R., Non-peptide poly(amino acids) for biodegradable drug delivery systems, in Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials (N. A. Peppas and R. J. Haluska, eds.). Controlled Release Society, Lincolnshire, IL, 1985, pp. 51-52. 

Wood, D. Biodegradable drug delivery systems. Int. J. Pharm. 7 1-18, 1980. 

ANIMAL MODELS USED TO TEST BIODEGRADABLE DRUG DELIVERY SYSTEMS... 

Cyclodextrins have proven to be the most popular enzyme mimics, catalyzing various reactions. Cyclodextrin-based neoglycoenzymes with improved efficiency have also been designed and synthesized. Cyclodextrin-modified enzymes have potential application as biosensors as well as in the formulation of effective and biodegradable drug delivery systems for enzyme replacement therapy [84]. 

Smith A, Hunneyball IM. Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration. International Journal of Pharmaceutics. 1986 30 215-220. 

Moore LA, Norton RL, Whitman SL, Drum RL. An injectable biodegradable drug delivery system based on acrylic terminated poly e-caprolactone. Annual Meeting of the Society of Biomaterials 1995. 

C.G. Pitt, T.A. Marks, and A. Schindler, Biodegradable Drug Delivery Systems Based on Aliphatic Polyesters Application to Contraceptives and Narcotic Antagonists. Naltrexone Res. Monogr., 28,1980. 

Mader, K, Domb, A.J., Sw artz, H.M. (1996) Gamma sterilization induced radicals in biodegradable drug delivery systems, /. Appl. Rad. Isotop. 

Two approaches are discussed for the preparation of enzymatically controlled drug delivery systems a calcium-responsive biodegradable drug delivery system based on a mixture of starch with HPMC (hydroxypropyl methyl cellulose ether) (biodegradable) and the starch hydrolytic enzyme, alpha-amylase, in its non-active form and a glucose responsive insulin delivery system based on the hydrogel poly(2-hydroxyethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate), with entrapped glucose oxidase, catalase and insulin. In both systems, the sensitivity... 

EL. Mi, Y.M. Lin, Y.B. Wu, S.S. Shyu, and Y. H. Tsai, Chitin/PLGA blend microspheres as a biodegradable drug-delivery system Phase-separation, degradation and release behavior. Biomaterials, 23, 3257-3267, 2002. 

Poly(elastin), another poly(peptide), is also being examined in both the medical and controlled release areas.20-32 Although this material is relatively new, and of synthetic origin, it could probably find utility in cosmetics. Other important poly(peptide) applications include their use as drug carriers,23 and biodegradable drug delivery systems.24... 

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