Delivery systems biodegradability

Zheng, A.H., Gao, J.Q., Zhang, Y.P., and Liang, W.Q. 2004. Aprotein delivery system biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres, biochem. Biophys. Res. Commun. 323 ... 

AUcock HR (1990) In Chasin M, hanger R (eds) Biodegradable polymers as drug delivery systems. Dekker, New York, chap 5, p 163... 

Various antimalarial drugs have been studied in biodegradable delivery systems. Wise (89) reported the use of a lactide/glycolide copolymer and also poly(L-lactic acid) for release of drugs such as quinazoline and sulfadiazine. Although in vitro data and experiments in mice were somewhat encouraging, these early formulations failed to reach significant clinical status. 

Cha, Y., and Pitt, C. C., A one-week subdermal delivery system for L-methadone based in biodegradable microspheres,... 

Pitt, C. G., and Schindler, A., Capronor A biodegradable delivery system for levonorgestrel, in Long-Acting Contraceptive Delivery Systems (G. I. Zatuchni, A. Goldsmith, J. D. Shelton, and J. J. Sciarra, eds.). Harper and Row, Philadelphia, 1984, pp. 48-63. 

Pitt, C. G., Gratzl, M. M., Jeffcoat, A. R., Zweidinger, R., and Schindler, A., Sustained drug delivery systems. II. Factors affecting release rates from poly( e-caprolactone) and related biodegradable polyesters, J. Pharm. Sci.. 68, 1534-1538, 1979. 

Pitt, C. G., Marks, T. A., and Schindler, A., Biodegradable drug delivery systems based on aliphatic polyesters application to contraceptives and narcotic antagonists, in Controlled Release of Bioactive Materials (R. Baker, ed.). Academic Press, New York, 1980, pp. 19-43. 

Kohn, J., and Langer, R., Non-peptide poly(amino acids) for biodegradable drug delivery systems, in Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials (N. A. Peppas and R. J. Haluska, eds.). Controlled Release Society, Lincolnshire, IL, 1985, pp. 51-52. 

Since the purpose of this book is to describe applications of biodegradable polymers to drug delivery systems, particularly from the perspective of the materials employed, the approach taken in this chapter has been to focus on the natural biodegradable polymers which have been used most extensively as matrices for the delivery of drugs. Consideration was also given to the fact that collagen has not been the subject of any recent reviews. 

Kohn, J. In Biodegradable Polymers as Drug Delivery Systems Chasin M. Langer, R., Eds. Drugs and the Pharmaceutical Sciences Marcel Dekker, Inc., New York, NY, 1990, Vol. 45, pp. 195-229. 

Biodegradable polyurethanes have been proposed and studied before (9-72). The difference in our study is the inclusion of a phosphoester linkage instead of the commonly used polyester component. This seems to provide more flexibility as the side chain of the phosphate or phosphonate can be varied. For controlled drug delivery applications, drugs can be linked to this site to form a pendant delivery system. Moreover, for certain medical applications, fast degradation rate is obtainable by the introduction of these hydrolyzable phosphoester bonds. With the LDI based polyurethanes, drugs or other compounds of interest can also be coupled to the ester side chain of the lysine portion. 

Biodegradable Polymers as Drug Delivery Systems, edited by Mark Chasin and Robert Langer... 

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