Biodegradable Drug Delivery System

AUcock HR (1990) In Chasin M, hanger R (eds) Biodegradable polymers as drug delivery systems. Dekker, New York, chap 5, p 163... 

Pitt, C. G., Gratzl, M. M., Jeffcoat, A. R., Zweidinger, R., and Schindler, A., Sustained drug delivery systems. II. Factors affecting release rates from poly( e-caprolactone) and related biodegradable polyesters, J. Pharm. Sci.. 68, 1534-1538, 1979. 

Pitt, C. G., Marks, T. A., and Schindler, A., Biodegradable drug delivery systems based on aliphatic polyesters application to contraceptives and narcotic antagonists, in Controlled Release of Bioactive Materials (R. Baker, ed.). Academic Press, New York, 1980, pp. 19-43. 

Kohn, J., and Langer, R., Non-peptide poly(amino acids) for biodegradable drug delivery systems, in Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials (N. A. Peppas and R. J. Haluska, eds.). Controlled Release Society, Lincolnshire, IL, 1985, pp. 51-52. 

Since the purpose of this book is to describe applications of biodegradable polymers to drug delivery systems, particularly from the perspective of the materials employed, the approach taken in this chapter has been to focus on the natural biodegradable polymers which have been used most extensively as matrices for the delivery of drugs. Consideration was also given to the fact that collagen has not been the subject of any recent reviews. 

Kohn, J. In Biodegradable Polymers as Drug Delivery Systems Chasin M. Langer, R., Eds. Drugs and the Pharmaceutical Sciences Marcel Dekker, Inc., New York, NY, 1990, Vol. 45, pp. 195-229. 

Biodegradable Polymers as Drug Delivery Systems, edited by Mark Chasin and Robert Langer... 

F Lescure, D Bichon, JM Anderson, E Doelker, ML Pelaprat, RJ Gurny. Acute histopathological response to a new biodegradable polypeptidic polymer for implantable drug delivery system. Biomed Mater Res 23 1299-1313, 1989. 

Poly-j3-malate is readily degraded completely to L-malic acid under both acid and base conditions [108], and it can also be hydrolyzed by enzymes within the cell [105,106]. Recently, several bacteria were isolated which were able to utilize poly-/i-malate as sole carbon source for growth [109]. Because the polymer is biodegradable and bioadsorbable, it is of considerable interest for pharmaceutical applications, especially in controlled-release drug delivery systems [97,98]. Chemical routes to poly-/ -malate are expected to provide materials with various properties [110]. 

Kumari A, Yadav SK, Yadav SC (2009) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B 75 1-18... 

Recently, biodegradable polymers have been used to fabricate macro- and nanometer scale self-assembled systems such as microspheres (MSs), nanospheres (NSs), polymer micelles, nanogels, and polymersomes (Fig. 1). These have attracted growing interest because of their potential utility for drug delivery systems (DDS), tissue engineering, and other applications. To construct these self-assembled systems... 

Jeong B, Choi YK, Bae YH et al (1999) New biodegradable polymers for injectable drug delivery systems. J Control Release 62 109-114... 

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