Bacteriostatic sodium chloride

Solution 0.9% sodium chloride (as bacteriostatic sodium chloride inj) Rx) Various... 

Bacteriostatic sodium chloride Newborns for fluid or sodium chloride replacement. 

Bacteriostatic sodium chloride Do not use in newborns. Benzyl alcohol as a preservative in bacteriostatic sodium chloride injection has been associated with toxicity in newborns. These solutions have not been reported to cause problems in older infants, children, and adults. 

Benzyl alcohol is a preservative that may be present in multidose vials of bacteriostatic sodium chloride and bacteriostatic water for injection and pharmaceuticals available in multidose vials for parenteral use. An association between the presence of benzyl alcohol in solutions used for flushing intravascular catheters and to reconstitute medications and a gasping syndrome and deaths in neonates was first reported in the early 1980s.The neonates also displayed clinical findings such as an elevated anion gap, metabolic acidosis, CNS depression, seizures, respiratory failure, renal and hepatic failures, cardiovascular collapse, and death. Those at highest risk were premature infants who weighted less... 

The drug dissolves instantly to give a clear solution having a pH in the range of 3.5-5.0. Vials of vinblastine sulfate should be stored in a refrigerator between 2 and 8 C to assure extended stability. After reconstitution with 10 mL bacteriostatic Sodium Chloride Injection USP (preserved with benzylalcohol), solution may kept in a refrigerator at 2° to 8°C for 30 days without significant loss of potency (102). ... 

Among single drug component studies, usual vehicles for dilution are 5% dextrose (D5W), 0.9% sodium chloride (normal saline, NS), aqueous buffers, peritoneal dialysis fluid, nonaqueous solvents, water for injection, phosphate-buffered saline, bacteriostatic water for injection, bacteriostatic sodium chloride. Ringer s injection, and lactated Ringer s. Stability studies can also be carried out on the drug product solution as such or in specific containers or injection devices. Solutions and suspensions can also be prepared extemporaneously and stability tested to show worthiness for oral, ophthalmic, or rectal administration. The following is an example of the first... 

IM administration Reconstitute cefepime with the following diluents Sterile Water for Injection, 0.9% Sodium Chloride, 5% Dextrose Injection, 0.5% or 1 % lidocaine hydrochloride, or Sterile Bacteriostatic Water for Injection with parabens or benzyl alcohol. 

To be reconstituted with 5 mL bacteriostatic 0.9% sodium chloride for injection, USP, with normal 0.9% benzyl alcohol as a preservative saline (pH in the range of 7.0-9.0) Per vial 30 mg mannitol SC... 

Etanercept is available as a preservative-free powder for reconstitution or as a solution in prefilled syringes. The powder should be reconstituted in bacteriostatic water, containing 0.9% benzyl alcohol, to a final concentration of etanercept of 25 mg/mL. The prefilled syringes contain 25 mg or 50 mg etanercept in a 1% sucrose solution containing sodium phosphate, sodium chloride and l-arginine. Both preparations are administered by subcutaneous injection. 

The culture is autoclaved, centrifuged, and acidified to pH 5.0-6.0 and is passed through a column containing 5 grams of Decalso S per liter of liquid. The adsorbed licheniformin is then eluted by a 10 % sodium chloride solution passed through the column. It is then precipitated as the picrate, which is converted to the hydrochloride, which, in turn, is purified by dissolving in methanol and reprecipitated with acetone. Thus, a yield of 40 to 50 mg. of material per liter of culture medium, is obtained without any loss of bacteriostatic activity. 

Certain antiseptic and therapeutic agents (such as sodium fluoride, stannous fluoride, strontium chloride, urea, dibasic ammonium phosphate, are used in dentrifrices for their anticarcinogenic, bacteriostatic and bactericidal actions. 

Streptomycin was inactivated by reducing and oxidizing agents. The bacteriostatic-activity of this antibiotic for Escherichia coli was reduced in the presence of cysteine, sodium thioglycolate, stannous chloride, sodium bisulfite, sodium hydrosulfide, sodium formate and sodium thiosulfate. Cysteine was the most active. Denkelwater, Cook and Tishler found that the cysteine inactivation of streptomycin could be reversed by iodine presumably cystine was formed during this process. Rake and Donovick inactivated streptomycin with semi-carbazide hydrochloride in order to test the sterility of concentrated streptomycin solutions. The inactivation of streptomycin by compounds containing sulfhydryl groups has been discussed by Cavallito. ... 

These residues from cleaning agents and other fluids containing surfactants (e.g., cetyl pyridinium chloride and cetyl trimethyl ammonium bromide) may have bacteriostatic effects or cause flavor taints. To determine quaternary ammonium compounds (QACs), they are first extracted into solvent (1,1,2,2-tetrachlor-ethane) and then detected by the formation of a pink color with dioctyl sodium sulfosuccinate (Aerosol T), which is quantified by spectrophotometry. 

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