Bacterial pathogen

Veterinary Potential or Fiorfenicol. The absolute ban on the use of chloramphenicol ia food producing animals ia the United States and Canada has accentuated the need for an effective broad spectmm antibiotic ia animal food medicine. Fiorfenicol and other antibiotics commonly used ia veterinary medicine have been evaluated in vitro against a variety of important veterinary and aquaculture pathogens. Some of these data ate shown in Tables 4 and 5, respectively. Fiorfenicol was broadly active having MICs lower than those of chloramphenicol in each of the genera tested (Table 4). Florfenicol was also superior to chloramphenicol, thiamphenicol, oxytetracycline [79-57-2] ampicillin [69-53-4] and oxolinic acid [14698-29-4] against the most commonly isolated bacterial pathogen of fish in Japan (Table 5) (37). 

Table 4. Activity of Florfenicol (2) and Chloramphenicol (1, R = NO2) Against Veterinary Bacterial Pathogens...

Table 5. Minimum Inhibitory Concentrations (MIC q ) of Florfenicol (2) and Other Antibiotics Against Bacterial Pathogens Isolated from Fish in Japan, Jg/mL...

Choi H.W. Kim Y.J. Lee S.C. Hong J.K. Hwang B.K. (2007) Hydrogen peroxide generation by the pepper extracellular peroxidase CaP02 activates local and systemic cell death and defense response to bacterial pathogens / / Plant Physiology. V. 145. P. 890-904. 

Acute pharyngitis presents a diagnostic and therapeutic dilemma. The majority of sore throats are caused by a variety of viruses fewer than 20% are bacterial and hence potentially responsive to antibiotic therapy. However, antibiotics are widely prescribed and this reflects the difficulty in discriminating streptococcal from non-streptococcal infections clinically in the absence of microbiological documentation. Nonetheless, Strep, pyogenes is the most important bacterial pathogen and this responds to oral penicillin. However, up to 10 days treatment is required for its eradication fixm the throat. This requirement causes problems with compliance since symptomatic improvement generally occurs within 2-3 days. 

Although viral infections are important causes of both otitis media and sinusitis, they are generally self-limiting. Bacterial infections m complicate viral illnesses, and are also primary causes of ear and sinus infections. Streptococcus pneumoniae and Haemophilus influenzae are the commonest bacterial pathogens. Amoxycillin is widely prescribed for these infections since it is microbiologically active, penetrates the middle ear, and sinuses, is well tolerated and has proved effective. 

Tenover EC. Hughes J.M. (1996) The challenges of emerging infectious diseases. Development and spread of multipity resistant bacterial pathogens. J Am Med Assoc, 275, 300-304. 

FIGURE 66-2. Important bacterial pathogens classified according to Gram stain and morphologic characteristics. (Reprinted from Rybak MJ, Aeschlimann JR. Laboratory tests to direct antimicrobial pharmacotherapy. In In DiPiro JT, Talbert RL, Yee GC, et al, (eds.) Pharmacotherapy A Pathophysiologic Approach. 6th ed. New York McGraw-Hill 2005 1894.)... 

Streptococcus pneumoniae is the most common bacterial pathogen associated with community-acquired pneumonia. 

TABLE 68-1. Common Bacterial Pathogens by Type of Pneumonia... 

Therefore, despite the 18% and 25% resistance to penicillin and macrolides, the clinical failure rate is less than this. Owing to the empirical treatment of CAP in the outpatient setting, establishing a meaningful clinical failure rate with any therapy is difficult to do. No studies have been performed that established a correlation between clinical failure rates with a particular antimicrobial agent and the percentage of resistant bacterial pathogens. 

List the most common bacterial pathogens that cause acute otitis media, acute bacterial rhinosinusitis, and acute pharyngitis. 

O Osteomyelitis is an infection of the bone that is associated with high morbidity and increased health care costs. The inflammatory response associated with acute osteomyelitis can lead to bone necrosis and subsequently chronic infections. Bacterial pathogens, particularly Staphylococcus aureus, are the most common microorganisms implicated in these infections. Diagnosis and treatment are often difficult due to the heterogeneous... 

O Vaccines provide active immunity against viral and bacterial pathogens. 

Patel, J. B. 16S rRNA gene sequencing for bacterial pathogen identification in the clinical laboratory. Mol. Diagn. 2001, 6, 313-321. 

Call, D. R. Borucki, M. K. Loge, F. J. Detection of bacterial pathogens in environmental samples using DNA microarrays. J. Microbiol. Meth. 2003, 53, 235-243. 

Events involving deliberate or accidental distribution of bacterial pathogens into our everyday environment have clearly defined the need for a sensitive, specific, and rapid method of bacterial detection. Bioterrorism was first introduced in the United States in 1984 with the Salmonella typhimurium attack in The Dalles, Oregon, by a cult group attempting to affect a local election.1 As a result of this act 751 people contracted salmonellosis, which totally overwhelmed the hospitals and medical clinics with patients. Later our society became keenly aware of the potential of bioterrorism during the last four months of 2001 when Bacillus anthracis (anthrax) spores were sent through the US mail in an envelope to several locations. These events had... 

DeLeo, F.R. (2004) Modulation of phagocyte apoptosis by bacterial pathogens. Apoptosis, 9 (4), 399-413. 

The objective of mastitis treatments is to cure the infected udders from the infection, but cure is defined in very different ways. For example, in economic terms, the farmer needs to achieve a level of udder health that allows expected milk yields and quality parameters specified by processors/ national regulations to be achieved. On the other hand, cure with respect to antibiotic treatments, is often defined in terms of absence of bacterial pathogens in milk (bacterial cure), with the proportion of cows without detectable pathogen presence following treatment being defined as the bacterial cure rate (BCR). The main problem with using BCR as the main indicator of cure is that it was frequently shown to include a proportion of cows with drastically elevated SCC values (indicative of sub-clinical mastitis) after treatment, but without clinical (sensory) symptoms. 

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