Autologous blood

Treatment of anaemia associated with chronic disease Treatment of anaemia associated with cancer/chemotherapy Treatment of anaemia associated with prematurity To facilitate autologous blood donations before surgery To reduce transfusion requirements after surgery To prevent anaemia after bone marrow transplantation... 

It is indicated in hypovolaemic shock, loss of blood and plasma (e.g., trauma, burns, preoperative autologous blood or plasma donation), and for priming the heart-lung machine. In addition, it can be used as a vehicle for various drugs. 

G. Other applications Epoetin alfa may find a place in the therapy of anemia of other diseases such as those associated with sickle cell disease, rheumatoid arthritis, and prematurity. In addition the potential for use in autologous blood transfusion programs merits study. 

N., Gerson, S. L., Cooper, B. W., et al. (2000), Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy, J. Clin. Oncol, 18(2), 307-316. 

Heiss, M.M. Mempel, W. Jauch, K.-W. Delanoff, C. Mayer, G. Mempel, M. Eissner, H.-J. Schildberg, E.-W. Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery. Lancet 1993, 342, 1328-1333. 

Thus, this study in sickle cell disease patients appeared to support the findings of a parallel study in normal human volunteers, where it was concluded that HBOC-201 apparently supported submaximal exercise capacity in a manner quite similar to autologous blood, but at lower pulse rate. Cl, and lactate concentration. The results of both studies suggest that the provision of acellular Hb may be an efficient way to deliver oxygen to the tissues. 

In some countries there has been a marked increase in the use of autologous blood transfusion, since it is known that blood-borne viruses, such as HIV, can be transmitted by allogeneic blood transfusion (24). 

Qutaishat S. Autologous blood transfusion evaluation of an alternative strategy in reducing exposirre to allogeneic blood transfusion. Immunol Invest 1995 24(l-2) 435-41. 

Hill SE, Leone BJ, Faithfull NS, Flaim KE, Keipert PE, Newman MF. Perflubron emulsion (AF0144) augments harvesting of autologous blood a phase II study in cardiac surgery. J Cardiothorac Vase Anesth 2002 16(5) 555-60. 

Parenteral nutrition was used to support a patient requiring autologous blood stem-cell transplantation, but vitamins were excluded (the reason was not identified). After about 28 days, the patient suddenly developed severe metabolic acidosis, heart failure, and deep coma. Thiamine was immediately infused, with rapid improvement. 

Hartmann JT, von Vangerow A, Fels LM, Knop S, Stolte H, Kanz L, Bokemeyer C. A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplantation. Br J Cancer 2001 84(3) 313-20. 

Hammer [82] conducted an experiment in which volunteers received either autologous blood or egg white by duodenal intubation to simulate the condition of upper gastrointestinal bleeding. [99mTc]-DTPA was added to each infusion and arrival at, and clearance from, the colon was recorded. At 4 h after the start of blood infusion, a median of 30% of counts was observed in the transverse colon compared to 0% after... 

Stiff PJ, Veum-Stone J, Lazarus HM, et al. FUgh-dose chemotherapy and autologous stem cell transplantahon for ovarian cancer An autologous blood and marrow transplant registry report. Ann Intern Med 2000 133 504-515. 

The 2007 Tour de France was marred by several scandals, including the expulsion of Kazakstan cycling star Alexandre Vinokourov, who was accused of having taken autologous blood transfusions to boost his red cell count. 

Emholic material Steel coils Platinum microcoils if co-axial system used 1. Glue 2. Thrombin 3. Long detachable coils or detachable balloons if the aneurysm must be packed Unless the haemorrhage is immediately life threatening (see Fig. 7.3) do not use Particles Gelfoam Autologous blood... 

Some radiopharmaceuticals are rather complex dosage forms. Radiolabelled nanospheres, nanoparticles, nanocolloids, peptides, monoclonal antibodies and glass particles for radioembolisation are a few examples. Also autologous blood cells can be radiolabelled, outside or inside the body. The radiolabelling of blood cells is used in routine practice. 

---