Atrial natriuretic peptide gene

Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, et al. 2006. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Nat Acad Sci USA. 27 13789-13794. 

Li, Q. and Gardner, D.G. (1994) Negative regulation of the human atrial natriuretic peptide gene by 1,25-dihydroxyvitamin D3. Journal ofBiologJcal Chemistry, 269, 4934-4939. 

ANF atrial natriuretic peptide CGRP calcitonin gene-related peptide VIP vasoactive intestinal peptide... 

The expression of the ET-1 gene is increased by growth factors and cytokines, including transforming growth factor-B (TGF-B) and interleukin 1 (IL-1), vasoactive substances including angiotensin II and vasopressin, and mechanical stress. Expression is inhibited by nitric oxide, prostacyclin, and atrial natriuretic peptide. 

Several hues of evidence confirmed the cardiomyocyte nature of the cells within the beating EBs (Fig. 12.2) [40]. Reversed-phase polymerase chain reaction (RT-PCR) studies demonstrated the expression of cardiac-specific transcription factors (e.g., GATA4 and Nkx2.5) and cardiac-specific structural genes [cTnl, cTnT, atrial natriuretic peptide (ANP), MLC-2V, MLC-2a]. Initial analysis of gene expression pattern during in vitro cardiomyocyte differentiation of the hES revealed a reproducible... 

A. Classification and Prototypes Vasoactive peptides comprise a large class of endogenous substances that function as neurotransmitters as well as local and systemic hormones. The better-known peptides include angiotensin, bradykinin, atrial natriuretic peptide, endothelin, vasoactive intestinal peptide, substance P, calcitonin gene-related peptide, vasopressin, glucagon, and several opioid peptides. Vasopressin is discussed in Chapters 15 and 37, the opioid peptides in Chapter 31, and glucagon in Chapter 41. The peptides discussed in this chapter and their effects are summarized in Table 17-1. 

Abbreviations used in this chapter AChR, acetylcholine receptor ANP, atrial natriuretic peptide ARIA, acetylcholine receptor-inducing activity AzC, L-azetidine CGRP, calcitonin gene related peptide 3,4 DHP, 3,4-dehydro-1-proline EDHB, ethyl-3,4-dihydroxybenzoate PCB, polychlorinated biphenyl. 

There are a number of other potential targets for gene transfer in ALI/ARDS. Adenoviral vector-mediated expression of atrial natriuretic peptide in rat lung airway and alveolar epithelium reduced development of pulmonary hypertension after hypoxic challenge (212). Adenovirus-mediated expression of a neutrophilic elastase inhibitor has been demonstrated in rat lung but not yet evaluated for efficacy in acute lung injury (213). Cationic liposome-mediated expression of Oj-antitrypsin in cultured CF bronchial epithelial cells decreased injury result-... 

Keck ME, Holsboer F (2001) Hyperactivity of CRH neiu-onal circuits as a target for therapeutic interventions in affective disorders. Peptides 22 835-844 Kellner M, Wiedemann K, Holsboer F (1992) ANF inhibits the CRH-stimulated secretion of ACTH and cortisol in man. Life Sci 50 1835-1842 Kellner M, Herzog L, Yassouridis A, Holsboer F, Wiedemann K (1995) A possible role of atrial natriuretic hormone in pituitary-adrenocortical imresponsiveness in lactate-induced panic disorder. Am J Psychiatry 152 1365-1367 Kennedy JL, Bradwein J, Koszycki D (1999) Investigation of cholecystokinin system genes in panic disorder. Mol Psychiatry 4 284-285... 

Mental activity involves adenosine, angiotensin, atrial natriuretic factor, bombesin, bradykinin, calcitonin, calcitonin-gene related peptide (CGRP), adrenomedullin, can-nabinoid, cholecystokinin and gastrin, corticotropin-releasing factor (CRF), glutamate, histamine, melatonin, somatostatin, thyrotropin-releasing hormone, and vasopressin and oxytocin. 

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