Neutrophil elastase inhibitor

Roberts, B., Markland, W., Ley, A., Kent, R., White, D., Guterman, S., and Ladner, R. (1992) Directed evolution of a protein selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage Proc Natl Acad Sci USA 89, 2429-2433. 

Inoue Y, Seiyama A, Tanaka H, Isao U, Akimau P, Nishino M, Shimazu T, Sugimoto H (2005) Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on LSP-induced acute dysfunction of the pulmonary microcirculation. Crit Care Med 33(8) 1814-1822 Inoue Y, Tanaka H, Ogura H, Ukai I, Fujita K, Hosotsubo H, Shimazu T, Sugimoto H (2006) A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury. 1 Trauma 60(5) 936-943... 

M. Padrines and J. O, Bieth. Hastin decreases Hie efficiency of neutrophil elastase inhibitors, Am. J Respir. Cell Mol BioL 4 187(1991). 

Roberts BL, Markland W, Siranosian K, Saxena, Guterman SK, Ladner RC, Protease inhibitor display M13 phage selection of high-affinity neutrophil, elastase inhibitors, Gene, 121 9-15, 1992. 

Utility Human Neutrophil Elastase Inhibitor in the Treatment of... 

Agents causing phospholipidosis amiodarone, chloroquine, DMP-777 (a neutrophil elastase inhibitor). 

Shi, Y., and Sharma, S. (1999) Metallopep-tide approach to the design of biologically active ligands Design of specific human neutrophil elastase inhibitors. Bioorg. Med. Chem. Lett. 9, 1469-1474. 

C. Boudier and J. G. Bieth. Oxidized mucus proteinase inhibitor a fairly potent neutrophil elastase inhibitor. Biochem. J. 303 61 (1994). 

Nitrogen heterocycles can be accessed by the same reductive cyclization strategy [75]. Modest yields of the desired products are obtained in these reactions (Eq. 64), which serve as intermediates in the synthesis of human neutrophil elastase inhibitors. 

In a second example, the Lessen rearrangement was utilized in the scale-up synthesis of neutrophil elastase inhibitor, ONO-6868, circumventing the need for a potentially explosive Curtius rearrangement reaction. Lessen transformation of 43 using 0-acetylated hydroxamate took place in refluxing THF/H2O condition. The yield for the rearrangement itself was not provided, however, the overall yield for conversion of 43 to 45 was reported to be 63%. ... 

Shintani, T. Takamoto, M. Sawada, M. Aishita, H. Nakagawa, T. Simultaneous determination of human neutrophil elastase inhibitor (ONO-5046) and its metabolite in plasma and urine by direct injection column-switching HPLC, J.Pharm.BiomedAnal., 1994,12, 397-405. 

There are a number of other potential targets for gene transfer in ALI/ARDS. Adenoviral vector-mediated expression of atrial natriuretic peptide in rat lung airway and alveolar epithelium reduced development of pulmonary hypertension after hypoxic challenge (212). Adenovirus-mediated expression of a neutrophilic elastase inhibitor has been demonstrated in rat lung but not yet evaluated for efficacy in acute lung injury (213). Cationic liposome-mediated expression of Oj-antitrypsin in cultured CF bronchial epithelial cells decreased injury result-... 

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