TRAIL apoptosis-inducing

HBV, hepatitis B HCV, hepatitis C IAP, inhibitor of apoptosis protein DBM, IAP binding motifs INCA, inhibitory CARD NASH, non-alcoholic steatohepatitis PCD, programmed cell death PCI, pan-caspase inhibitor OA, osteoarthritis RA, rheumatoid arthritis Smac, second mitochondria-derived activator of caspases TRAIL, tumor necrosis factor-related apoptosis-inducing ligand. 

TRAIL tumor necrosis factor-a-related apoptosis-inducing ligand... 

European researchers found recently that retinoic acid-induced apoptosis in leukemia cells was mediated by paracrine action of tumor-selective death ligand trail (tumor necrosis factor-related apoptosis-inducing ligand) [4]. 

Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. 2005. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). 

Shankar S, Chen Q, Sarva K, Siddiqui I, Srivastava RK. 2007. Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells Molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal 2 10. 

Li M, Ona VO, Guegan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM (2000) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288 335-339 Li H, Zhu H, Xu CJ, Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 491-501 Lin Y, Devin A, Cook A, Keane MM, Kelliher M, Lipkowitz S, Liu ZG (2000) The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase. Mol Cell Biol 20 6638-6645... 

M. A. De Esposti, W. C. Dougall, P. J. Smolak, J. Y. Wau, C. A. Smith, and R. G. Goodwin. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity, 1, (6), 813-820, 1997. 

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