Chemo-sensitizers

Nogi H, Kobayashi T, Suzuki M, et al. EGFR as paradoxical predictor of chemo-sensitivity and outcome among triple-negative breast cancer. Oncol. Rep. 2009 21 413-417. 

It is worth stressing that in the use of the coated LPG as a refractometer, and not as chemical sensor, the sPS layer acts just as a passive HRI layer and no chemical interaction with surrounding medium occurs. Therefore, any HRI overlay could be used for the refractometry, not necessarily a chemo-sensitive one as the sPS. However, in this work the same material has been used for both applications taking advantage of the experience ripened in its deposition. 

The number of chemical sensors based on LPGs coated with a chemo-sensitive overlay is still quite limited and even lower is the number of those sensors for which the phenomenon of the modal transition is knowingly used to enhance the performances of the devices. Some of them are based on overlays with low refractive index and/or on thick overlays, which have the drawback of slow diffusion limited response times. One application that seems to attract particular interest is the measurement of the relative humidity (RH). 

Deeb DD, Jiang H, Gao X, Divine G, Dulchavsky SA, Gautam SC. 2005. Chemo-sensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis. J Exp Ther Oncol 5 81-91. 

CDD has developed and deployed a robust preliminary public antimalarial database from five sources which hosts data on approximately 16,000 public compounds. The growth of this database has fostered several key antimalarial discovery collaborations between CDD users. A substructure search for the known chemo-sensitizer substructure led to the identification of hundreds of compounds for laboratory evaluation by the laboratories of... 

Dolak, Y. Hillen, T. Cattaneo models for chemo-sensitive movement—numerical solution and pattern formation. J. Mathematical Biology 2003, 46 (5), 460 78. 

Sargent JM, Taylor CG (1989) Appraisal of the MTT Assay as a Rapid Test of Chemo-Sensitivity in Acute Myeloid Leukaemia. Brit J Cancer 60 206... 

Comparing both transport processes, it is evident, that thermo-sensitive gels can respond faster to the environmental change than chemo-sensitive gels. 

Although tumor cell death is controlled by several mechanisms, one of the dominant mechanisms involves mitochondria [91], It is thus rational to target the mitochondria for therapeutic purposes due to its critical role in the regulation of apoptosis. One potential target is the mitochondrial permeability transition pore (MPTP), the most significant component of which appears to be the peripheral benzodiazepine receptor known as the translocator protein [92]. Various ligands for the translocator protein have shown both anti-proliferative and pro-apoptotic activity or may act as chemo-sensitizers via modulation of MPTP [93-95]. 

Chemoprevention, 2177, 2179 Chemopreventive, 2598, 2601,4114, 4115,4127 action, 2643 effects, 1412 potential, 1422 Chemo-profiles, 2960 Chemoprotective, 3483,4119, 4126 Chemoreceptor trigger zone, 1374 Chemorepellent, 336, 337 Chemo-sensitizing, 2176 Chemotactic activity, 336 Chemotaxonomic marker, 3221 Chemotaxonomic studies, 940 Chemotaxonomy, 3174, 3540 Chemotherapeutic, 3489, 4114,... 

Chemo-sensitive polymers including sensors and bioactive electrodes are frequently used for chemical detection. Chitosan is also used for sensor applications, particularly biosensors due to its low biotoxicity, excellent film-forming property, and high... 

Villalona-Calero MA, Otterson GA, Wientjes MG, Weber F, Bekaii-Saab T, Young D, Murgo AJ, Jensen R, Yeh T-K, Wei Y, Zhang Y, Eng C, Grever M, Au JLS. Non-cytotoxic suramin as a chemo-sensitizer in patients with advanced nonsmall-cell lung cancer a phase 11 study. Ann Oncol 2008 19 1903-9. 

Pepper DR, Landauer RC, Kumar P. Effect of charybdotoxin on hypoxic chemo-sensitivity in the adult rat carotid-hody, in vitro. J Physiol 1995 487P 177P-178P. 

In this model of dopaminergic chemotransduction, the apparent aforementioned paradox may be resolved if one considers that the enhanced catecholamine content and general carotid body hyperplasia xmder chronic hypoxia are associated with an enhanced number of functional chemoreceptor units (composed of at least one glomic cell and one sensitive nerve ending forming a synapse) within the carotid body (Fig. 1). In this pattern, the overall activity of the carotid sinus nerve (which conveys the chemo sensitive information from the carotid body to the brainstem respiratory centers) may be enhanced as well as dopamine content. 

Katsman, A., Umezawa, K., and Bonavida, B. (2007). Reversal of resistance to cytotoxic cancer therapies DHMEQ as a chemo-sensitizing and immuno-sensitizing agent. Drug Resist. Updat. 10, 1-12. 

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