FLICE inhibitory protein

DISC, death inducing signaling complex DSS, dextran sulfate sodium FLIP, caspase-8 (FLICE) inhibitory protein... 

T3. Thome, M., Schneider, R, Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J. L., Schroter, M., Scaffidi, C., Krammer, P. H., Peter, M. F., and Tschopp, J., Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386,517-521 (1997). 

Zhang, X.D., Franco, A., Myers, K., Gray, C., Nguyen, T., Hersey, P., 1999. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. Cancer Res. 59, 2747-2753. 

Researchers have discovered that Fas-mediated apoptosis is blocked by a molecule that has been assigned various names, but is usually referred to as c-FLIP (cellular FLICE-inhibitory protein) (other names include FLAME, I-FLICE, Casper, etc.) [34,35]. The expression of c-FLIP is down-regulated by IL-2 [36,37], a fact which explains why IL-2 can sensitize activated T-cells to Fas. 

NOD.H-2 mice, 7-8 weeks old were divided into four groups and fed with normal, 20-fold 100-fold and 1000-fold high iodine water for 24 weeks. Fas, FasL and FLICE inhibitory protein (FLIP) on thyroid epithelial cells and infiltration cells were identified. 

Olsson A, Diaz T, Aguilar-Santelises M. Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actino-... 

Djerbi M, Scrpanti V, Catrina Al, Bogen B, Biberfeld P, Grandien A (1999) The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors [see comments]. J Exp Med 190 1025-1032... 

Fig. 1. Modulation of apoptosis by v-FLIP and v-Bcl-2. v-FLIPs specifically inhibit apoptosis mediated by death receptors. v-lCA specifically targets caspase-8 and inhibits its activation. v-Bcl-2 and vMIA inhibit those apoptotic pathways that are signaled through mitochondrial release of cytochrome c. FADD, Fas-associated death domain FLICE, FADD-like interleukin-converting enzyme CARD, cas-pase-recruiting domain PTPC. permeability transition pore complex FLIP, FLICE-inhibitory protein vie A, viral inhibitor of caspase 8-induced-apoptosis MIA. viral mitochondrial inhibitor of apoptosis Apcif-l, apoptotic protease-activating factor 1...

Ritthipichai K, Nan Y, Bossis I, Zhang Y. Viral FLICE inhibitory protein of rhesus monkey rhadinovirus inhibits apoptosis by enhancing autophagosome formation. PLoS One. 2012 7(5) e39438. doi 10.1371/joumal.pone.0039438. 

Chanvorachote, R, Nimmannit, U., Wang, L., Stehlik, C., Lu, B., Azad, N., and Rojanasakul, Y. (2005). Nitric oxide negatively regulates fes cd95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of flice inhibitory protein. J. Biol. Chem. 280, 42044-42050. 

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