Antimony tartrate tartar emetic

It is oxidized to antimony pentoxide, 86205 on treatment with nitric acid and forms potassium antimony tartrate (tartar emetic, KSb(OH)2 C4H2O6) when heated with acid potassium tartrate. 

SYNS ANTLMONYL POTASSIUM TARTRATE EMETIQUE (FRENCH) ENT 50,434 POTASSIUM ANTIMONYL TARTRATE Q POTASSIUM ANTIMONYL-d-TARTRATE POTASSIUM ANTIMONY TARTRATE TARTAR EMETIC TARTARIZED ANTIMONY TARTRATE ANTIMONIO-POTASSIQUE (FRENCH) TARTRATED ANTIMONY... 

Arsenic salts and arsines are extremely toxic, and uses of arsenic compounds in weedkillers, sheep- and cattle-dips, and poisons against vermin are less widespread than was once the case (see Box 14.1). Antimony compounds are less toxic, but large doses result in liver damage. Potassium antimony tartrate tartar emetic) was used medicinally as an emetic and expectorant but has now been replaced by less toxic reagents. Bismuth is one of the less toxic heavy metals and compounds, such as the subcarbonate (Bi0)2C03, find use in stomach remedies including treatments for peptic ulcers. 

Synonyms Antimonyl potassium tartrate Potassium antimonyl tartrate Potassium antimony tartrate Tartar emetic Tartarized antimony... 

Antimony potassium tartrate (tartar emetic) has the advantage of being low in cost. It has been called the dmg of choice for Schistosoma japonicum infection (204) even though it fails to cure the disease in many patients. However, trivalent antimonials are no longer recommended for the treatment of helminthic infections because these compounds have an unacceptable toxicity and are too difficult to administer (205). 

AntimonyCIII) phosphate, 3 65 Antimony potassium tartrate (tartar emetic), 3 66 Antimony red, 3 44 Antimony selenide, 3 57 Antimony sesquioxide. See Antimony trioxide... 

J. Puffin and P. Rend, Antimoine Anti-biotique The public fortunes of the secret properties of antimony potassium tartrate (tartar emetic) , J. Hist. Med., 1991, 46, 44(M56. 

The tartrate complex of antimony(III), tartar emetic, K2[Sb2(J-C406H2)2]-3H20, has been known in medicine for over 300 years and is used for treatment of schistosomiasis and leishmaniasis the toxic side effects can be mediated by penicillamine. In the salts the ion has a binuclear structure [Fig. 10-9(b)] and the Sb atom... 

Potassium amimonyl tartrate tartar emetic, KSbOC H Og) and some other compounds of antimony are used in medic ine. 

Antimony Potassium Tartrate Potassium Antimonyl Tartrate Tartar Emetic Tartarized Antimony Tartrated Antimony ... 

Antimony Potassium Tartrate (Tartar Emetic) Diloxanide Furoate (revised structure)... 

Antimony(III) tartrate and potassium Sb tartrate (tartar emetic), K2[Sb2(C4H206)2]-3H20, are soluble. 

Current Therapy - Parenteral antimonials include antimony potassium tartrate (tartar emetic) or the corresponding sodium salt, Stibophen (Puadin) [pentasodium antimony bis (catechol-3 5-oral drugs now in use are lucanthone (Miracil D) (XlXa) and niridazole (IX). A human... 

Tartaric acid is noteworthy for a) the excellent way in which the majority of its salts Crystallise, and h) the frequent occurrence of salts having mixed cations. Examples of the latter are sodium potassium tartrate (or Rochelle salt), C4H40 NaK, used for the preparation of Fehling s solution (p. 525), sodium ammonium tartrate, C4H OaNaNH4, used by Pasteur for his early optical resolution experiments, and potassium antimonyl tartrate (or Tartar Emetic), C4H404K(Sb0). The latter is prepared by boiling a solution of potassium hydrogen tartrate (or cream of tartar ) with antimony trioxide,... 

For the production of tartar emetic (antimony potassium tartrate [28300-74-5]), potassium bitartrate [868-14 ] and antimony oxide, Sb202, are added simultaneously to water in a stainless-steel reactor. The reaction mixture is diluted, filtered, and collected in jacketed granulators where crystallization takes place after cooling. Centrihiging, washing, and drying complete the process. 

Tartar emetic was the subject of controversy for many years, and a variety of iacorrect stmctures were proposed. In 1966, x-ray crystallography showed that tartar emetic contains two antimony(III) atoms bridged by two tetranegative D-tartrate residues acting as double bidentate ligands to form dipotassium bis[D-p.-(2,3-dihydroxybutanedioato)]diantimonate [28300-74-5] (41). 

Antimony compounds have been used to treat leishmaniasis ever since tartar emetic (antimony potassium tartrate) was discovered early in the 20th century to have efficacy against the mucocutaneous form of the disease. The cutaneous form has been treated with tartar emetic formulated in an ointment. Many side effects have been seen with this trivalent antimonial, some of which can be ascribed to the difficulty of obtaining pure antimony for its manufacture. These side effects include toxicity to the heart, Hver, and kidneys. Other promising trivalent antimonials have been abandoned in favor of pentavalent antimonials with lower toxicity. 

Potasso-tartrate of Antimony—KO, SbO, C8 H4 Ojg, IIO—is extensively used in medicine under the name of tartar emetic. Throe parts of oxide of antimony arc made into a thin paste with water, and. mixed with. four parts of bitartrate of potassa., The. mixture is digestad for several hours, and then boiled with eight parts of water. The boiling-hot solution is filtered and allowed to crystallize. Transpareat or opaque, colorless, shining rhombic octahedra, of metallic taste. It is soluble in fifteen parts of cold aud two of boiling water. In small doses. it is an emetic in larger doses it is a poison., ... 

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