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Antimicrobial agents/drugs lipid solubility

The unbound drug in the systemic circulation is available to distribute extravascularly. The extent of distribution is mainly determined by lipid solubility and, for weak organic acids and bases, is influenced by the pK3/pH-dependent degree of ionization because only the more lipid-soluble non-ionized form can passively diffuse through cell membranes and penetrate cellular barriers such as those which separate blood from transcellular fluids (cerebrospinal and synovial fluids and aqueous humour). The milk-to-plasma equilibrium concentration ratio of an antimicrobial agent provides a reasonably... [Pg.218]

See other pages where Antimicrobial agents/drugs lipid solubility is mentioned: [Pg.15]    [Pg.284]    [Pg.1345]    [Pg.3957]    [Pg.3959]    [Pg.16]    [Pg.21]    [Pg.35]    [Pg.39]    [Pg.100]    [Pg.210]    [Pg.218]    [Pg.219]    [Pg.247]    [Pg.255]    [Pg.256]    [Pg.284]    [Pg.2038]    [Pg.4]    [Pg.58]   
See also in sourсe #XX -- [ Pg.133 ]



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Antimicrobial drugs

Drug solubility

Drugs Soluble

Lipid solubility

Lipid solubility, antimicrobial drug

Lipid-soluble

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