Antimicrobial drugs pregnancy

In reality, most information about the safety of antimicrobial drugs in pregnancy comes from a history of long-term use with no reported adverse outcomes. As has been emphasized (317) most practitioners are happy... 

Several groups of antimicrobial drugs are relatively safe in pregnancy, including penicillins and cephalosporins. While the macrolide azithromycin appears to be safe, the use of the esto-late form of erythromycin is associated with an increased incidence of cholestasis in the pregnant patient. Studies in animals have shown that clarithromycin is potentially embryotoxic. The answer is (A). 

Antimicrobial history Drug allergy history Renal and hepatic function Concomitant medications Pregnancy or lactation Compliance potential... 

Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. In Kaufmann DW, editor. Antimicrobial and Parasite Agents. Littleton, MA John Wright, 1982 296, 435. 

Several host factors should be considered when evaluating apatient for antimicrobial therapy. The most important factors are drug allergies, age, pregnancy, genetic or metaboUc abnormalities, renal and hepatic function, site of infection, concomitant drug therapy, and underlying disease states. 

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