Antibody-forming cell response

Hiddinga HJ, Isaak DD, Lewis RV (1994b) Enkephalin-containing peptides processed from proenkephalin significantly enhance the antibody-forming cell responses to antigens. J Immunol 152 3748-3759. 

Guo TL, White KL Jr, Brown RD, Declos KB, Newbold RR, Weis C, Germolec DR, McCay JA. Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(l) generations of Sprague-Dawley rats. Toxicol Appl Pharmacol 2002 181 219-227. 

Immunosuppressive effects have been obtained in vitro with mercuric chloride. A marked inhibition of the mixed lymphocyte reaction in mice as well as PFC (plaque forming cell) response to SRBC (sheep red blood cells) by mercuric chloride [166] has been reported. Chronic exposure to mercury of rabbits gave immunosuppression, measured as low antibody titres to viral agents [167], A suppression of antibody production in chickens exposed to mercuric chloride has also been reported [168]. Furthermore, an inhibition of mitogenic response to PHA in lymphocytes by mercuric chloride has been obtained [169],... 

Humoral-mediated immunity LPS (lipopolysaccharide) mitogen response or F(ab)2 mitogenic response enumeration of plaques by IgM antibody-forming cells to a T-dependent antigen (sheep red blood cells serum IgM concentration... 

Two different classes of white cells (lymphocytes) are associated with the immune response The B cells and the T cells. B cells produce antibodies that are secreted and aggregated foreign substances known as antigens. T cells are of different types Some of them assist B cells to become antibody-forming cells others mount an attack on antigens of their own. 

A key feature of the clonal selection theory is that each antibody-forming cell or clone is committed to the expression of one antibody. The diversity in the response is a consequence of the great variety of distinct clones. Initially, Burnet (1957) assumed that antibody diversification occurs exclusively early in life, by a random... 

In a 14 day corn oil gavage study, 600 and 800 mg kg were found to be lethal to both sexes of rats. Liver and kidney toxicity as well as decreased antibody-forming cells were evident at 250 mg kg in male and female mice when administered for 14 days. The magnitude of the effects was less than that observed with the other THMs. Inhalation exposure to 240 or 24 ppm bromoform for 10 or 60 days, respectively, caused effects in liver and kidney. Fetotoxic response was observed after gavage administration at 50, 100, or 200 mg kg on gestation days 6-15. 

Depression of the primary antibody plaque-forming cell response in rats suggests that methoxyethanol could inhibit the humoral immune system. Testicular atrophy and depression of sperm counts are noted in animal studies. Methoxyethanol, along with several other known testicular toxins, causes an increase in the urinary creatine/creatinine ratio as one of the earliest and most sensitive markers of testicular damage after acute exposure. Methoxyethanol is considered to be a mild skin and eye irritant. Methoxyethanol is not a contact sensitizer. 

Song H, Cerny I Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen. J Exp Med 2003 198(12) 1923-1935. 

Gallium arsenide has been shown to be an immunosuppressant. When administered intratracheally to mice at concentrations between 50 and 200 mg kg GaAs suppressed the in-vivo antibody-forming cell (AFC) response to sheep erythrocytes (SRBC), and interfered with antigen processing that is essential for CD4+ T-cell stimulation by splenic macrophages (Sikor-ski etal. 1991, Lewis TA etal. 1996). The arsenic moiety appears to be responsible... 

D. Humoral Immunity The B lymphoid cells, which are capable of differentiating into antibody-forming cells, are responsible for humoral immunity. The humoral response is triggered when B lymphocytes bind antigen via their surface immunoglobulins. The antigens are internal-... 

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