Antibody-forming cells

Janah S, Hussain QZ, Chaudhuri SN. 1970. Effect of hydrocortisone on immune cytokinetics. Part 1-Effects of different dose schedules on 19S and 7S antibody forming cells in Jeme s plaque technique. Indian J Med Res 58 1206-1216. 

Mouse 28 d (Swiss- 7 d/wk Webster) 24 hr/d 1.6 (decreased spleen and thymus weight, decreased leukocyte count, decrease in antibody titer following intraperitoneal immunization decreased splenic antibody forming cells) Hillam and Ozkan 1986 Pb(N03)2... 

Wang, C.H., Korenaga, M., Greenwood, A. and Bell, R.G. (1990) T-helper subset function in the gut of rats differential stimulation of eosinophils, mucosal mast cells and antibody-forming cells by OX8 OX22 and OX8 OX22+ cells. Immunology 71, 166-175. 

Humoral-mediated immunity LPS (lipopolysaccharide) mitogen response or F(ab)2 mitogenic response enumeration of plaques by IgM antibody-forming cells to a T-dependent antigen (sheep red blood cells serum IgM concentration... 

Treatment for transplant rejection is a very important application of glucocorticoids. The efficacy of these agents is based on their ability to reduce antigen expression from the grafted tissue, delay revascularization, and interfere with the sensitization of cytotoxic T lymphocytes and the generation of primary antibody-forming cells. 

The development of hybridoma technology by Milstein and Kohler in 1975 revolutionized the antibody field and radically increased the purity and specificity of antibodies used in the clinic and for diagnostic tests in the laboratory. Hybridomas consist of antibody-forming cells fused to immortal plasmacytoma cells. Hybrid cells that are stable and produce the required antibody can be subcloned for mass culture for antibody production. Large-scale fermentation facilities are now used for this purpose in the pharmaceutical industry. 

Two different classes of white cells (lymphocytes) are associated with the immune response The B cells and the T cells. B cells produce antibodies that are secreted and aggregated foreign substances known as antigens. T cells are of different types Some of them assist B cells to become antibody-forming cells others mount an attack on antigens of their own. 

B cell. One of the major types of cells in the immune system. B cells can differentiate to form memory cells or antibody-forming cells. 

The second half of the chapter considers restrictions on and elaborations of the process of gene rearrangement. Allelic exclusion—the expression of an allele from only one chromosome of a pair—assures that each antibody-forming cell will produce antibodies of only a single specificity, as postulated by the clonal selection hypothesis. The preimmune repertoire is modified after exposure to antigen an... 

A key feature of the clonal selection theory is that each antibody-forming cell or clone is committed to the expression of one antibody. The diversity in the response is a consequence of the great variety of distinct clones. Initially, Burnet (1957) assumed that antibody diversification occurs exclusively early in life, by a random... 

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