Amino acids compounds

The reaction of ort/io-phthalaldehyde and a thiol compound with an amino acid to form an isoindole derivative can be used to enhance the detection sensitivity for the normally only weakly UV-detectable amino acid compounds, and to introduce an... 

Finally, the solubility of the amino acids is also important. Only those amino acids that are readily soluble in water, such as glycine, alanine, valine, and proline, can be employed to construct the present family of 3d-4f amino acid compounds. 

Fig. 10.8 SAR by MS applied to the A1061 construct (see text), (a) Structures of key motifs screened against the RNA target. Compound A is a D-amino acid. Compounds B1 and B2 are quinoxalin-2,3-diones. Compound AB is the rigid biaryl linked compound, (b) Binding affinity for the motifs when screened individually as well as binding affinity for motifs when screened in competition experiments are shown. Binding...

Bivalirudin is a synthetic 20-amino acid compound. The molecular weight is 2180 Da and the plasma half-life is 25 minutes, Bivalirudin can bind to both fibrin-bound thrombin and free thrombin. Dose reduction in proportion to the creatinine level is necessary in patients with renal insufficiency. 

Karentz, D., McEuen, F. S., Land, M. C., and Dunlap, W. C., Survey of microsporine-like amino acid compounds in Antarctic marine organisms potential protection from ultraviolet exposure, Mar. Biol. 

Teai, T., Drollet, J. H., Bianchini, J. P., Cambon, A., and Martin, P. M. V., Widespread occurence of mycosporine-like amino acid compounds in scleractinians from French Polynesia, Coral Reefs, 16, 169, 1997. 

Karsten, U. and Garcia-Pichel, F., Carotenoids and mycosporine-like amino acid compounds in members of the genus Microcoleus (cyanobacteria) a chemosystematic study, Syst. Appl. Microbiol., 19, 285, 1996. 

The study of the detailed energetics of dissolution of amino acid compounds from the crystalline phase into water has received less attention, due largely to experimental difficulties associated with low... 

Ni", Cu11 mixed-ligand amino-acid compounds 904... 

So as to expand the methodology by incorporating a cyclic amino acid, compound 53 was treated with sodium prolinate in hot DMSO to afford the crude substitution adduct 58 (Scheme 9). Subsequent cyclodehydration using acetic anhydride provided the pyrido[3,4-b]pyrrolizidin- 1-one S949 in high overall yield for the two steps. Following the protocol... 

Whelan, J.K., and Emeis, K. (1992) Sedimentation and preservation of amino acid compounds and carbohydrates in marine sediments. In Productivity, Accumulation, and Preservation of Organic Matter Recent and Ancient Sediments (Whelan, J.K., and Farrington, J.W., eds.), pp. 176-200, Columbia University Press, New York. 

Manganese(II) is quite distinctly a class (a) metal This is manifest, for example, in the preference for O donor rather than N donor ligands, so that amino acid compounds become simply those of substituted carboxylates, and there is currently little evidence for the N bonding of peptides that leads to the interesting chemistry of the peptide compounds of the later transition metals. Of P and As ligands but little is known, although recent work suggests the possibility that this may become... 

Betaxanthins are immediately recognized by their characteristic absorption spectra, which show a maximum at 475 nm. On alkaline or acid hydrolysis, they yield the corresponding amino acids. In a more recent approach (77) the betaxanthins were cleaved with 0.6 N aqueous ammonia to yield betalamic acid (3) and the corresponding amino acids. Compound 3 was then extracted with organic solvents and characterized as its dimethyl ester. Unknown amino acids were identified by GC-MS of their A -trifluoroacetyl methyl ester derivatives. 

Anal3Ttical and Synthetical Study of Proteins.—Fischer attacked the problem of the constitution of proteins from the synthetic side. Assuming that proteins consist of units of amino acids, as indicated by the analytical study of their hydrolytic products, he attempted to synthesize, from amino acids, compounds of similar complexity to the proteins. As already stated (p. 386), he found that the double anhydrides, resulting from the esters of amino acids by the loss of two molecules of alcohol from two molecules of the ester, took up one molecule of water when treated with dilute alkali and a single anhydride was obtained. The reactions may be represented as follows ... 

In the series of cyclopropane amino acids, compounds 651,652 and 653 have also been studied. The cyclopropyl analogs 651 and 652 showed distinctly lower activity than the corresponding amino acids histidine and thyroxine Compounds 653 were tested for their behavior towards several hydroxylase, aminotransferase and decarboxylase enzyme systems The cis isomer had no inhibitory effect . 

Serum creatinine is an amino acid compound derived from the metabolism of creatine in skeletal muscle and from dietary meat intake [35]. The serum creatinine concentration (Scr) is a commonly used marker for the estimation of adequate renal function due to the fact that it is released into the plasma at a relatively constant rate, is freely filtered by the glomerulus, and is not metabolized nor reabsorbed by the kidney. Various reference ranges for the Scr take into consideration differences in age and gender (Table 5), but fail to consider other variables such as race, body weight and muscle mass. As a result, a Scr within the reference... 

Hydrogenation reactions that are efficiently controlled by chiral Rh-phosphine catalysts involve those carbon-carbon double bonds substituted with carboxylic and amide groups. They are precursors of a-amino acids, compounds that are very important protein building blocks. The best substrate is (Z)-a-acetamidocinnamic acid 10 ... 

Amino acid Compound with both an amino group and a carboxylic acid. Amino acids form the building blocks of proteins. 

Natural product extracts are generally complex and comprise mixtures of neutral, acidic, basic, lipophilic, hydrophilic, and amphiphilic (e.g., amino acids) compounds and, as a consequence, there is rarely one method that will serve for all eventualities. It is sometimes worthwhile to carry out H or NMR spectroscopy of the extract or fraction to determine the class of compound(s) to be separated (1)—deuterated NMR solvents are cheap ( 1.00 for CDCI3) and 1 D NMR experiments are quicker to run than the extensive... 

Amino acids - Compounds containing both a carboxylic acid group (-COOH) and an amino group (-NH ). The most important are the a-amino acids, in which the -NH group in attached to the C atom adjacent to the -COOH group. In the [5-amino acids, there is an intervening carbon atom. [4]... 

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