Amino acids as synthons for heterocyclic compounds

Amino acids as synthons for heterocyclic compounds 95AHC(64)1. 

Tisler, M., Kolar, P., Amino Acids as Synthons for Heterocyclic Compounds,... 

Amino acids as synthons for heterocyclic compounds, 64, 1 f-Amino effect, 14, 211, 65, 1 A-Aminoazoles, 53, 85... 

Pyrrolinones are important synthons in the preparation of many important compounds including amino acids, various alkoids and many natural products. These heterocyclic derivatives have also been shown to express anti-tumor properties. In addition, they are inhibitors of cyclooxygenase-2 (COX-2), and HIV-1 protease. They also possess several important and exploitable medicinal properties. Pyrrolinones can be synthesized from functionalized imino-alkynes via cyclohhydrocarbonylation in the presence of a zwitterionic rhodium catalyst (ZW) 106 with both high regioselectivity and chemoselectivity as well as in good overall yield (Table 2-3). This versatile reaction system allows for easy access to important synthons. ... 

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