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Peptide compounds

However, most natural peptides are composed of L-form a-amino acids and because of the ubiquitous prevalence of peptidases they have limited biostability, and consequently low bioavailability. Thus, a novel field of peptidomimetics has emerged in drug discovery, in attempts to design non-peptide compounds mimicking the pharmacophore and thus the activity of the original peptide. [Pg.254]

The development of modem methods, suitable for the analysis of ampholytes in biological fluids, provided means for isolating from urine some chemically better defined fractions containing peptide compounds. The methods used did not, however, exclude the existence of some other forms of combined amino acids in the fractions studied. [Pg.128]

Traditionally, amino acids have been utilized in the mainstream of organic chemistry primarily as building blocks for peptide syntheses. One may expect that in the future the use of amino acids as starting materials for non-peptide compounds will be a subject of ever-increasing interest. Many chiral target molecules with widely variable structures will be prepared from amino acids in the future. [Pg.235]

One of the main drivers for the development of new pulmonary drug delivery systems has been the potential for noninvasive systemic delivery of protein and peptide compounds. The systemic delivery of macromolecules via the airways would overcome the inconvenience and cost associated with current methods of administration (injection), and appears likely given the large surface area of the airways and the thin pulmonary epithelium. Most research has concentrated on pulmonary delivery of insulin for the treatment of diabetes. Recently, one insulin product has completed phase three studies and is now undergoing review by European regulatory agencies for marketing approval. [Pg.243]

Pavia, M. R. Whitesides, G. M. Hangauer, D. G. Hediger, M. E. A Method for Preparing and Selecting Pharmaceutically Useful Non-Peptide Compounds from a Structurally Diverse Universal Library WO 95/04277, 1995. [Pg.78]

The third group consists of naturally occurring and synthetic peptides with opioid-like properties. The opioid peptides were discovered during the search for endogenous ligands of the opioid receptors and share the same action and side-effect profile as the non-peptidic compounds... [Pg.127]

Purely synthetic non-peptidic compounds with opioid properties but non-morphinan structure... [Pg.151]

In conclusion, the investigation of peptidic and non-peptidic tool compounds for the 5 receptor have demonstrated the potential use of 5 agonists and antagonists for a variety of clinical applications, especially for the treatment of pain. Full exploitation of this potential will however only be possible with ideal non-peptidic compounds having high potency, selectivity and, above all, optimal drug metabolism and pharmacodynamic characteristics. [Pg.463]

The patellins 1-6 (382-387) and trunkamide A (388) [298, 299] along with tawicyclamides A (389) and B (390) [300] represent another variation of the cyclic peptides produced by Lissoclinum species. All of these compounds lack the characteristic oxazoline ring present in most Lissoclinum cyclic peptides. Compounds 382-386 and 388 were inactive in a series of in vitro cytotoxicity assays while 387, 389, and 390 showed modest cytotoxicity, supporting the importance of the presence of the oxazoline ring for cytotoxic activity [298, 300],... [Pg.882]

In Section II.C we will present novel tricyclic xanthene derived amino acid templates, which allow the construction of libraries of cyclic conformationally constrained peptide loop mimetics using the split-and-mix method without having to use tagging and deconvolution strategies. In Section III we will focus on parallel and combinatorial approaches devoted to the synthesis of small molecule, non-peptidic compound collections, which in addition offer the possibility to incorporate structural features derived from protein epitope mapping into conformationally constrained peptide mimetics. [Pg.22]

With these words Vittorio Erspamer depicted the rational basis of the pharmacological research on peptides and proteins of the amphibian skin. This 10-year period of research has shown that amphibian skin, with its generally large peptide content, offers a rich source of secretory peptide compounds, analogues of mammalian neuropeptides and hormones. [Pg.175]

Studies in this laboratory for the past several years have been concerned with the elucidation of the latter steps in this series of reactions. Specifically, efforts have been directed toward the characterization of the reaction involving the transfer of aminoacyl sRNA to mammalian ribonucleoprotein particles, the enzymatic and cofactor requirements, and possible intermediates in this process. The evidence obtained indicates that aminoacyl transfer is an enzymatic reaction requiring at least two enzyme fractions, which have been resolved and partially purified, GTP and a sulfhydryl compound further, the possibility exists that a ribosome-bound sRNA-amino acid (or peptide) compound is formed as an intermediate in this reaction. [Pg.65]

Functionalized 1,2,3-triazoles 86 and 87 were prepared by [2 + 3] cycloadditions of resin-bound a-azido esters 85 with substituted alkynes <02TL4059>. Regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of resin-bound alkynes 88 with azides afforded solid-supported 1,2,3-triazoles 89, which were ligated further to give 1,4-substituted-1,2,3-triazole peptide compounds <02JOC3057>. [Pg.219]

Manganese(II) is quite distinctly a class (a) metal This is manifest, for example, in the preference for O donor rather than N donor ligands, so that amino acid compounds become simply those of substituted carboxylates, and there is currently little evidence for the N bonding of peptides that leads to the interesting chemistry of the peptide compounds of the later transition metals. Of P and As ligands but little is known, although recent work suggests the possibility that this may become... [Pg.9]


See other pages where Peptide compounds is mentioned: [Pg.371]    [Pg.100]    [Pg.130]    [Pg.189]    [Pg.49]    [Pg.124]    [Pg.333]    [Pg.125]    [Pg.132]    [Pg.477]    [Pg.1]    [Pg.324]    [Pg.39]    [Pg.1692]    [Pg.510]    [Pg.96]    [Pg.9]    [Pg.156]    [Pg.140]    [Pg.571]    [Pg.272]    [Pg.289]    [Pg.577]    [Pg.254]    [Pg.49]    [Pg.125]    [Pg.2]    [Pg.405]    [Pg.121]    [Pg.121]    [Pg.829]    [Pg.298]    [Pg.414]    [Pg.114]    [Pg.232]   


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