Amines ethylamine

In a search for routes to periannelated systems containing a thieno-thiophene fragment, the reactions of 239 with primary amines (ethylamine, aniline, -nitroaniline, and cyclohexylamine) were studied. The ratio of dichloromethyl thienothiophene to amine varied from 1 1 to 1 4, but only diamines 242 were found, and no periannelated compounds of type 243 [Eq. (83)]. 

A large family of other N-substituted homologues of 2,4-DMA were similarly prepared from the above ketone and sodium cyanoborohydride. Methyl-amine, ethylamine, propylamine, isopropylamine and hexylamine gave the corre-... 

Amines Ethylamine, trimethyl amine, isobutylamine, morpholine, cyclohexylamine... 

Nitrogen Compounds. Aliphatic and aromatic amines—ethylamine and aniline—resist hydrolysis even under extreme conditions, though the production of a-naphthol from a-naphthylamine under pressure is recorded. 

The nitrosation mechanism of aliphatic amines by metal nitrosyl complexes was studied with various secondary amines and one primary amine (ethylamine) using pentacyanonitrosylferrate (sodium nitroprusside). Very little mechanistic information is available for reactions with other metal nitrosyl complexes (see also Sects. 2.3, 4.3, and 7.2). 

The primary amine ethylamine attacks at C3 of HFPO (1) to yield an acyl fluoride that reacts further to afford iminoamide but the tertiary amine... 

Di-l-propynyl ketone (MI-90) and primary amines (ethylamine, isopropyl-amine) or amino acids that are unsubstituted in the a-position (glycine, ll-alanine, e-aminocaproic acid, glycylglycine, glycylleucine, alanylglycine) give enamines (W-91), which form V-substituted lutidones when their sodium salts are heated in water or their esters are heated in xylene. When 2-substituents are present, cyclization oocurs when their calcium salts or amides are heated in aqueous alkali. When heated in the presence of Triton B and DMF, a-alanyl-amide and di-I-propynyl ketone give the lutidone. ... 

Tables 10.2 and 10.3 lists the physical properties of the aliphatic amines. The lowest molecular weight amine, ethylamine, boils at only 16.6 C and is thus available only as a compressed gas or as an aqueous solution. The other fifteen aliphatic amines have boiling points in the range of 32.4-213 C. The flash points of these amines are low with the highest being only 70 F for the tributylamine. These short-chain amines are readily soluble in water and most organic solvents. The solubility of amines decreases with increasing temperature, for example, triethylamine is completely soluble in water below 18 C but is only partially soluble above this temperature. The lower alkylamines have the characteristic ammonia odor which decreases with increased substitution onto the nitrogen atom.

Aliphatic amines (ethylamine, 2-propanamine, 1-propanamine, N-ethyl-ethanamine, and 1-butanamine)... 

Dimethylamine is a secondary amine ethylamine is a primary amine. 

Acetophenone similarly gives an oxime, CHjCCgHjlCtNOH, of m.p. 59° owing to its lower m.p. and its greater solubility in most liquids, it is not as suitable as the phenylhydrazone for characterising the ketone. Its chief use is for the preparation of 1-phenyl-ethylamine, CHjCCgHslCHNHj, which can be readily obtained by the reduction of the oxime or by the Leuckart reaction (p. 223), and which can then be resolved by d-tartaric acid and /-malic acid into optically active forms. The optically active amine is frequently used in turn for the resolution of racemic acids. 

Imines. The group >C=NH is named either by the suffix -imine or by citing the name of the bivalent radical R R C< as a prefix to amine. For example, CH3CH2CH2CH=NH could be named 1-butanimine or butylideneamine. When the nitrogen is substituted, as in CH2=N—CH2CH3, the name is A-(methylidene)ethylamine. 

A number of 2eohtic materials have been claimed to cataly2e this reaction and reaction temperatures are on the order of 200—350°C with pressures as high as 18000 kPa (2600 psi) reported. This is a low conversion process and recycle of the unconverted starting materials is necessary to provide an economical process. Amination of ethylene to produce ethylamines cataly2ed by ammonium iodide is reported, but not beheved to be practiced commercially (15,16). Alkyl Halide Amination (Method 7). The oldest technology for pioducing amines is the reaction of ammonia with an alkyl hahde. This... 

Thioureas. Thioureas (11) are typically made from primary amines and carbon disulfide. The amine can be ethylamine, butylamine. 

To minimize the formation of fuhninating silver, these complexes should not be prepared from strongly basic suspensions of silver oxide. Highly explosive fuhninating silver, beheved to consist of either silver nitride or silver imide, may detonate spontaneously when silver oxide is heated with ammonia or when alkaline solutions of a silver—amine complex are stored. Addition of appropriate amounts of HCl to a solution of fuhninating silver renders it harmless. Stable silver complexes are also formed from many ahphatic and aromatic amines, eg, ethylamine, aniline, and pyridine. 

Sodium is soluble in ethylenediamine (16,17), but solubiHty in other amines such as methyl- or ethylamine may require the presence of ammonia. Sodium solubiHty in ammonia and ethylenediamine solutions has been extensively investigated (18). Sodium is insoluble in most hydrocarbons and is... 

Reaction of ethyl chloride with an alcohoHc solution of ammonia yields ethylamine, diethylamine, triethylamine, and tetraethyl ammonium chloride (10,11) (see Amines, lower aliphatic). 

Ethylamines. Mono-, di-, and triethylamines, produced by catalytic reaction of ethanol with ammonia (330), are a significant outlet for ethanol. The vapor-phase continuous process takes place at 1.38 MPa (13.6 atm) and 150—220°C over a nickel catalyst supported on alumina, siUca, or sihca—alumina. In this reductive amination under a hydrogen atmosphere, the ratio of the mono-, di-, and triethylamine product can be controlled by recycling the unwanted products. Other catalysts used include phosphoric acid and derivatives, copper and iron chlorides, sulfates, and oxides in the presence of acids or alkaline salts (331). Piperidine can be ethylated with ethanol in the presence of Raney nickel catalyst at 200°C and 10.3 MPa (102 atm), to give W-ethylpiperidine [766-09-6] (332). 

Amines Methylamine Dimethylamine Ethylamine Diethylamine Propylamine Dipropylamine Isopropylamine Diisopropylamine Butylamine ferf-Butylamine Allyl amine Cyclohexylamine... 

The method described is rather general. With appropriate modifications for the purification of the aim ne the method yields a- -tolylethylamine (72 per cent), a-p-chlorophenylethyl-amine (65 per cent), a -/)-bromophenylethylamine (63 per cent), a- -xenylethylamine (66 per cent), and a-(/9-naphthyl)-ethylamine (84 per cent) from the corresponding ketones. 

The reactions of (174) with various amines has been studied." " Hydrolysis of the hexamine salt of (174) gave not the symmetric diamine but (184) via a cyclic intermediate. The pyrolysis of 5-methyl-2-thenyltrimethyl ammonium hydroxide (185) is claimed to give (186) through a 1,6 Hofmann elimination reaction. The Bischler-Napieralski cyclization has been applied to acetyl derivatives of 2-(2-thienyl) ethylamine and 2-(3-thienyl) ethylamine for the preparation of sulfur analogs of isoquinoline. ... 

Amine bound to a Wang-polystyrene resin 381 was acylated with 4-oxo-4Ff-pyrido[l,2-u]pyrazine-3-carboxylic acid in the presence of bromotrispyrrolidinophosphonium hexafluorophosphate and /-Pr2NEt in A-methylpyrrolidone (98MIP16). l-(4-Cyclohexyl-4-r / r-butylaminocarbo-nyl-l-piperidyl)-2-(4-fluorophenyl)ethylamine was acylated with perhydro-pyrido[l,2-u]pyrazine-3-carboxylic acid (01MIP19). An amino group of a macrocyclic compound attached to a solid support was acylated with... 

A mixture of 142.5 g of "Rosin Amine D" containing about 70% dehydroabietylamine and 30% dihydro and tetrahydroabietylamine, 47.0 g of ethylene dibromide, and 60.6 g of tri-ethylamine is dissolved in 350 cc of anhydrous xylene and refluxed for about 16 hours. Thereafter the triethylamine dibromide salt formed Is separated from the solution by filtering the cool reaction mixture and washing with ether. The solution is then concentrated under reduced pressure to dryness to remove the ether, xylene and excess triethylamines present. 

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