Ames’ mutagenicity

Acute oral toxicity (rat)3 Ames mutagenicity screening test (Salmonella typhimurium)... 

Young SS, Gombar VK, Emptage MR, Cariello NE, Lambert C. Mixture deconvolution and analysis of Ames mutagenicity data. Chemo Intell Lab Sys 2002 60 5-22. 

TEST allows for estimates of the value for several toxicity endpoints [29] 96 h Fathead minnow LC50, 48 h Daphnia magna LC50, 48 h Tetrahymena pyriformis IGC50, Oral rat LD50, bioaccumulation factor, developmental toxicity, and Ames mutagenicity. TEST also estimates several physical properties... 

Table 17 Ames mutagenicity data for Salmonella typhimurium TA100 and physicochemical parameters for A-acyloxy-A-alkoxyamides together with predicted activities according to QSAR (Equation 4)... 

Kronberg L, Vartiainen T (1988) Ames mutagenicity and concentration of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and of its geometric isomer E-2-chloro-3-(dichloromethyl)-4-oxo-butenoic acid in chlorine-treated tap waters. Mutat Res 206 177-182... 

Norway has a standardized test program for permit derivation, comprising the Ames mutagenicity test, acute and chronic toxicity tests, and a biodegradation test. For monitoring purposes, it is advised to start screening the toxicity of an effluent with a comparatively large... 

Chao, L. Wang, L.K. Wang, M.H.S. Use of the Ames Mutagenicity Bioassay as a Water Quality Monitoring Method, PB88-168422/AS US Department of Commerce, National Technical Information Service Springfield, VA, 1986 25 p. 

Aeschbachter, H. L. and H. P. Wurzner. An evaluation of instant and regular coffee in the Ames mutagenicity test. Toxicol Lett 1979 5 139-145. 

CA232 Blair, C. A. and T. Shibamoto. Ames mutagenicity tests of overheated brewed coffee. Food Chem Toxicol 1984 22(12) 971-975. 

While animal experiments are only now underway, the tosylates have been examined in the Ames mutagenicity test system (16). 

Weinstein, D.. Katz, M. Kazmer, S. (1981) Use of a rat/hamster S-9 mixture in the Ames mutagenicity assay. Environ. Mutag., 3. 1-9... 

They must provide end products that meet minimal input requirements for Ames mutagenicity testing. 

Negative-Ion Chemical Ionization Mass Spectrometry and Ames Mutagenicity Tests of Granular Activated Carbon Treated Waste Water... 

The modified Ames mutagen assay was used to investigate the mutagenic potential of nitrosated fru-trp, a fru-trp control, and a nitrite control incubated in solutions under mild conditions (37°C, pH 4, 24 h). Figure 1 shows dose response curves obtained with S. typhimurium TA98 and TA100. Nitrosated fru-trp demonstrated a positive dose-response relationship with both tester strains in the absence of S-9 mix and a somewhat reduced dose-response relationship in its presence. The fru-trp and nitrite controls did not manifest mutagenic properties in either tester strain. 

Hye-Won A, Jeffrey EH. 1994. Effect of aluminum on fluoride uptake by salmonella typhimurium TA98 implications for the Ames mutagenicity assay. J Toxicol Environ Health 41 357-368. 

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