Mutagenicity, Ames test

TEST allows for estimates of the value for several toxicity endpoints [29] 96 h Fathead minnow LC50, 48 h Daphnia magna LC50, 48 h Tetrahymena pyriformis IGC50, Oral rat LD50, bioaccumulation factor, developmental toxicity, and Ames mutagenicity. TEST also estimates several physical properties... 

Norway has a standardized test program for permit derivation, comprising the Ames mutagenicity test, acute and chronic toxicity tests, and a biodegradation test. For monitoring purposes, it is advised to start screening the toxicity of an effluent with a comparatively large... 

Aeschbachter, H. L. and H. P. Wurzner. An evaluation of instant and regular coffee in the Ames mutagenicity test. Toxicol Lett 1979 5 139-145. 

CA232 Blair, C. A. and T. Shibamoto. Ames mutagenicity tests of overheated brewed coffee. Food Chem Toxicol 1984 22(12) 971-975. 

While animal experiments are only now underway, the tosylates have been examined in the Ames mutagenicity test system (16). 

They must provide end products that meet minimal input requirements for Ames mutagenicity testing. 

Negative-Ion Chemical Ionization Mass Spectrometry and Ames Mutagenicity Tests of Granular Activated Carbon Treated Waste Water... 

N-Acetylcysteine is negative in the Ames mutagenicity test and also reduces the mutagenic affect of chemical carcinogens in the same assay. 

Aminoanthraquinone 46a is widely used in vat dye manufacture. It has induced tumor formation171. Some vat black dyes (BB, P2R, 8R, and acridones) made from 46a have tested positive in the Ames mutagenicity test. Similar considerations apply to 2-aminoanthraquinone (46b). Certain aminoanthraquinone-derived vat dyes have been reported as posing little or no risk172,173. 

Neither saccharin nor any of the usual impurities present in commercial material is active in the Ames mutagenicity test.79 The metabolism of saccharin,80 of saccharin impurities,81 and of other saccharin derivatives82 has been studied. 

Johnson, B.T. 1992. Rainbow trout liver activation systems with the Ames mutagenicity test. Environ. Toxicol. Chem. 9 1183-1192. 

Cell Growth Inhibition Ames Mutagenicity Test... 

Schimmer, O., A. Kruger, H. PauUni, and F. Haefele. 1994. An evaluation of 55 commercial plant extracts in the Ames mutagenicity test. Pharmazie 49 448-451. 

Mutagenic activity of chilies (species unspecified) and the compound capsaicin was observed in the Ames mutagenicity test with Salmonella typhimurium with metabolic activation from S9 mix (Nagabhushan and Bhide 1986). 

In the Ames mutagenicity test with Salmonella typhimurium strains TA98, TAIOO, TA1535, TA1537, and TA1538, no mutagenic activity of an oleyl alcohol eluant extract of wild yam was observed with or without metabolic activation (Hooker 2004). 

No mutagenic activity was observed for motherwort in the Ames mutagenicity test (Schimmer et al. 1994). 

White, R.D., P.H. Krumperman, P.R. Cheeke, and D.R. Buhler. 1983. An evaluation of acetone extracts from six plants in the Ames mutagenicity test. Toxicol. Lett. 15(1) 25-31. 

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