Mutagenic action Ames test

Safety of Enterosgel preparation in terms of mutagenic action has been shown in the tests for induction of chromosome aberrations in bone marrow cells, in cultured human peripheral blood lymphocytes, and in the Ames test for induction of reversible gene mutations in Salmonella typhimurium. 

Ames BN, Durston WE, Yamasaki E, Lee FD (1973) Carcinogens are mutagens a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 70 2281-2285 Cunningham AR, Klopman G, Rosenkranz HS (1998) Identification of structural features and associated mechanisms of action for carcinogens in rats. Mutat Res 405 9-27 Dearden JC (2003) In silico prediction of drug toxicity. J Comput Aided Mol Des 17 119-127... 

Apart from toxicity tests involving the use of live animals, there are other ways of evaluating the toxic properties of chemicals that stem from an understanding of their mode of action. For example, the Ames test aids in the identification of substances that act as carcinogens or mutagens in mammals. Also, the study of the relationship between structure and toxicity (i.e., quantitative structure-activity relationships or QSARs) can provide support for the identification of toxic substances. These approaches will become more viable as molecular mechanisms of toxicity become better known, and they can lead to an understanding of the molecular characteristics that cause a chemical to interact adversely with cellular macromolecules. 

Glycidol is mutagenic, testing positive in the histidine reversion-Ames test. There is no report of its carcinogenic action. Oral and intraperitoneal administration of glycidol in rats showed harmful effects on fertility. 

No carcinogenic actions in animals or humans have been reported. The histidine reversion-Ames test for mutagenicity was inconclusive. 

Severe eye irritant can cause skin burns irritant action and toxicity lower than ethylenimine moderately toxic by all routes of exposure inhalation of 500 ppm for 4 hr was lethal to rats tested positive to histidine reversion — Ames test for mutagenicity produced tumors in blood, brain, and skin in animals A2 — suspected human carcinogen TLV-TWA sMn 2 ppm ( 5 mg/m ) (ACGIH, MSHA, and OSHA), IDLH 500 ppm (NIOSH) ... 

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