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Alkylating agents mutagenicity

Epichlorohydrin is an alkylating agent (mutagenic, affects DNA). Epichlorohydrin is also an irritant, sensitizer, and corrosive. [Pg.1039]

Alkylating agents are also mutagenic substances that have been used in cancer chemotherapy. Alkylating agents such as nitrogen or... [Pg.238]

J. H. Kim and J. J. Thomas, Use of 4-(nitrobenzyl)pyridine (4-NBP) to test mutagenic potential of slow-reacting epoxides, their corresponding olefins, and other alkylating agents. Bulletin of Environmental Contamination and Toxicology, 1992, 49(6), 879-885. [Pg.122]

Epichlorohydrin is a direct-acting mutagen by virtue of its activity as an alkylating agent. ° It causes genetic damage in most bacterial and mammalian test systems in vivo and in vitro. [Pg.295]

Ethylenimine is a direct-acting alkylating agent that is mutagenic in a wide range of test systems. ... [Pg.332]

BPL is a direct-acting alkylating agent and forms DNA adducts. It is mutagenic in a wide variety of in vitro and in vivo systems, both in somatic and germ cells. The lARC has determined that BPL is carcinogenic in experimental animals and that it is possibly carcinogenic to humans. ... [Pg.601]

Vogel, E. and Natarajan, A.T. The relation between reaction kinetics and mutagenic action of monofunctional alkylating agents in higher eukaryotic systems Interspecies comparisons. IN deSerres, F.J. and Hollaender, A., eds. Chemical Mutagens Principles and Methods for Their Detection, Volume 7. New York Plenum Press. 1982. p. 295-336. [Pg.134]

Friedman, J. and Huberman, E. (1980). Postieplication repair and the susceptibility of Chinese hamster cells to cytotoxic and mutagenic effects of alkylating agents, Proc. Nath Acad. Sd. 77,6072. [Pg.138]

Diepoxybutane is a potent bifunctional alkylating agent which reacts with DNA in vitro and in vivo. As a result, it is mutagenic in virtually all test systems including effects in somatic and germ cells of mammals exposed in vivo. In vivo, it induced DNA adducts, dominant lethal mutations and gene mutations in mice chromosomal aberrations... [Pg.201]

Pope, S., Baker, J.M. Parish, J.H. (1984) Assay of cytotoxicity and mutagenicity of alkylating agents by using Neurospora spheroplasts. Mutat. Res., 125, 43-53... [Pg.217]

Thier, R., Muller, M., Taylor, J.B., Pemble, S.E., Ketterer, B. Guengerich, F.P. (1995) Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. Chem. Res. Toxicol., 8, 465-472... [Pg.221]

Roldan-Arjona, T., Luque-Romero, F.L., Ruiz-Rubio, M. Pueyo, C. (1990) Quantitative relationship between mutagenic potency in the Ara test of Salmonella typhimurium and carcinogenic potency in rodents. A study of 11 direct-acting monofunctional alkylating agents. Carcinogenesis, 11, 975-980... [Pg.1414]

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See also in sourсe #XX -- [ Pg.627 ]



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