Acting Alkylating Agents

TABLE 2. Transformation of Golden Syrian Hamster Embryo Cells by Direct-Acting Alkylating Agents 

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Dimethyl carbamoyl chloride is a direct-acting alkylating agent with a wide spectrum of genotoxic activity." ACGIH has classified dimethyl carbamoyl as A2-a suspected human carcinogen with no threshold limit value (TLV). 

Ethylenimine is a direct-acting alkylating agent that is mutagenic in a wide range of test systems. ... 

BPL is a direct-acting alkylating agent and forms DNA adducts. It is mutagenic in a wide variety of in vitro and in vivo systems, both in somatic and germ cells. The lARC has determined that BPL is carcinogenic in experimental animals and that it is possibly carcinogenic to humans. ... 

It is a slow acting alkylating agent. After oral administration, it shows adequate and reliable absorption and almost completely metabolised. 

P-Propiolactone is a direct-acting alkylating agent that reacts with polynucleotides and DNA, mainly at N7 of guanine and NI of adenine, to form carboxyethyl derivatives. It also forms adducts with the N of cytosine and thymine (Hemminki, 1981 Lawley, 1984). It is genotoxic to a wide range of organisms in vitro and in vivo. 

Genotoxic carcinogens Primary, direct acting Alkylating agents Dimethylsulphate... 

Direct acting alkylating agents AlkyInitrosoureas As Initiators with a Promoter Polycyclic aromatic hydrocarbons Certain Arylamines Carbamic acid esters. Urethane As Promoters or Cocarcinogens with Initiation Phorbol esters Anthralin Catechol... 

Tumorigenkity Ethylene oxide is a direct-acting alkylating agent and a low potency mutagen. Cancer risk has been studied in two cohorts of workers exposed to ethylene... 

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