Alginates microsphere

Ribeiro, A. J., Neufeld, R. Arnaud, P. Chaumeil, J. C. (1999). Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres. International Journal of Pharmaceutics, Vol. 187,1, (September 1999), pp. (115-123), ISSN 0378-5173 Rubinstein, A. (1995). Approaches and opportunities in colon-specific drug-delivery. Critical Reviews in Therapeutic Drug Carrier Systems, Vol 12, 2-3,1995), pp. (101-149), ISSN 0743-4863... 

Boninsegna, S., Dal Toso, R.D., Dal Monte, R. and Carturan, G. (2003) Alginate microspheres loaded with animal cells and coated by a siliceous layer. Journal of Sol-Gel Science and Technology, 26, 1151-1157. 

Liu J, Zhang Y, Yang T, Ge Y, Zhang S, Chen Z, Gu N (2009) Synthesis, characterization, and application of composite alginate microspheres with magnetic and fluorescent functionalities. J Appl Polym Sci 113 4042 1051... 

Zhang, F., Guo, J., Peng, X., Fi, Y. (2004) Preparation and release behaviour of carboxy-methylated chitosan/alginate microspheres encapsulating bovine serum albumin. Journal of Applied Polymer Science, 92, 878-882. 

Microspheres (10 to 200 pm in diameter) of poly(fumaric acid—cose-bacic acid) anhydride (20 80) [P(FA SA)] were shown to exhibit very strong and pronounced mucoadhesive properties both in vitro and in vivo.143 145 The microspheres were tested for their effect on GI transit of low-molecular-weight drugs salicylic acid and dicumarol. As compared with the control (drug-loaded alginate microspheres of similar size), the P(FA SA) microspheres significantly delayed the GI transit of these drugs in rats.145... 

Brown JQ, Srivastava R, McShane MJ. Encapsulation of glucose oxidase and an oxygen-quenched fluorophore in polyelectrolyte-coated calcium alginate microspheres as optical glucose sensor systems. Biosensors Bioelectronics 2005, 21, 212-216. 

Zhu H, Srivastava R, Brown JQ, McShane MJ. Combined physical and chemical immobihzation of glucose oxidase in alginate microspheres improves stability of encapsulation and activity. Bioconjugate Chemistry 2005, 16, 1451-1458. 

Fig. 8. Spray device for the preparation of calcium alginate microspheres...

Rajinikanth, P. S., Sankar, C., and Mishra, B. (2003), Sodium alginate microspheres of metoprolol tartarate for intranasal systemic delivery Development and evaluation, Drug Deliv., 10, 21-28. 

Fig. 3 p -Galactosidase expression in tissues of mice inoculated orally with alginate microspheres containing plasmid DNA (A) liver (B) intestine and (C) spleen sections from the animal inoculated with microspheres containing bovine adenovirus type 3 (BAd3). (D) Liver (E) intestine and (F) spleen sections from the animal inoculated with microspheres containing LacZ plasmid +, BAd3. (From Ref. l)... 

Mittal, S.K. Aggarwal, N. Sailaja, G. van Olphen, A. HogenEsch, H. North, A. Hays, J. Moffatt, S. Immunization with DNA, adenovirus or both in biodegradable alginate microspheres effect of route of inoculation on immune response. Vaccine, in press. 

Chan LW, Lee HY, Heng PW. Production of alginate microspheres by internal gelation using an emulsification method. Int J Pharm 2002 242(1-2) 259-262. 

Gursoy A, Cevik S. Sustained release properties of alginate microspheres and tabletted microspheres of diclofenac sodium. ] Microencapsul 2000 17(5) 565-575. 

Since vaccines are quite susceptible to low pH in the stomach and enzymatic degradation in the GI tract, various methods have been tried to improve the vaccine delivery. Alginate microspheres have been examined to deliver vaccines by oral administration (38). Vaccine-containing... 

Bowersock TL, Hogenesch H, Suckow M, Porter RE, Jackson R, Park H, Park K. Oral vaccination with alginate microsphere systems. J Contr Rel 1996 39 209-220. 

Srivastava R, Brown JQ, Zhu HG, et al. (2005) Stable encapsulation of active enzyme by application of multilayer ntmofilm coatings to alginate microspheres. Macromol Biosci 5 717-727... 

Lee, D.W. Hwang, S. J. Park, J.B. Park, H.J. Preparation and release characteristics of polymer-coated and blended alginate microspheres. Journal of Microencapsulation 20, 179-192, 2003. 

Alexakis, T., Boadi, D. K., Quong, D., Groboillot, A., O Neill, I. K., Poncelet, D., and Neufeld, R. J. Microencapsulation of DNA within alginate microspheres and crosslinked chitosan membranes for in vivo application. Appl. Biochem. Biotechnol. 50 (1995) 93-106. 

Bowersock, T. L., HogenEsch, H., Suckow, M., Guimond, P, Martin, S., Borie, D., Torregrosa, S., Park, H., and Park, K. Oral vaccination of animals with antigens encapsulated in alginate microspheres. Vaccine 17(13-14) (1999) 1804-1811. 

Alginate microspheres have been extensively used as delivery system because they are very easy to prepare, the process is very mild, and virtually any ingredient can be encapsulated (Vladisavljevic and Williams, 2005). That is the reason why they are chosen to exemplify the use of the membrane and channel emulsification processes to produce gel particles. 

Lanza, R.R Kiihtreiber, W.M. Ecker, D. Staruk, J.E. Chick, W.L. Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres. Transplantation 1995, 59 (10), 1377-1384. 

Chan LW, Heng PW. Effects of polyfvinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification. Journal of Microencapsulation. July-August 1998 15(4) 409-420. PubMed PMID 9651863. 

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