In situ-forming hydrogel

Ruel-Gariepy, E., and Leroux, J. C. (2004), In situ-forming hydrogels—Review of temperature-sensitive systems, Eur. J. Pharm. Biopharm., 58,409-426. 

Kissel T, Li YX, Unger E. ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly (ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins. Adv. Drug Deliv. Rev. 2002 54 99-134. 

K.-D. Park, Y.-K. Joung, K.-M. Park, E.-G. Lih, In situ-forming hydrogel for tissue adhesive and biomedical use thereof, US0156164 [107]... 

Wound healing is a complex process that can be compromised by several factors. The wound healing efficacy of calcium alginate fibers in non-woven pads or ropes as well as in situ formed hydrogels can be further improved by incorporating dmgs or growth factors. 

Balakrishnan, B., Mohanty, M., Umashankar, P.R., Jayakrishnan, A. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatine. Biomaterials 26, 6335-6342 (2005)... 

Shrinkage, swelling, and evaporation. This is a short discussion of environmental effects that one needs to be aware of and account for in rheological data of in situ forming hydrogels and other polymeric materials. 

Tae G, Komfield JA, HubbeU JA. Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol). Biomaterials 2005 26(25) 5259-5266. 

Okino et also demonstrated dmg permeability into tissues from in situ forming hydrogels. Photopolymerized hydrogels based on styrene-derivatized gelatin were formed on the surface of rat liver tissue and rhodamine-albumin was used as a dmg model to characterize dmg release and diffusion into the tissue. This work showed the multitude of variables inherent to photopolymerizable systems to control dmg release characteristics. 

Nanjawade, BK Manvi, FV Manjappa, AS. In situ-forming hydrogels for sustained ophthalmic drug delivery. J Control Rel, 2007,122, 119-134. 

Gariepy, ER Leroux, JC. In situ-forming hydrogels— review of temperature-sensitive systems. EurJPharm Biopharm, 2004, 58, 409-426. 

Gariepy ER, Leroux JC (2004) In situ-forming hydrogels - review of temperature-sensitive systems. Eur J Pharm Biopharm 58 409-426... 

Macromers for use in forming in situ formed hydrogels generally comprise of a water soluble crosslinking agent, and a water soluble crossbnkable polymer (50). Examples of both kinds of compounds are shown in Table 8.7. 

Censi R, Fieten PJ, Di Martino P, Hennink WE, Vermonden T. In-situ forming hydrogels by tandem thermal geUing and Michael addition reaction between thermosensitive triblock copolymers and thiolated hyaluronan. Macromolecules. 2010 43 5771-8. 

Choi Bogyu, Loh Xian Jun, Tan Aloysius, et al. Introduction to in situ forming hydrogels for biomedical applications. In In-situ gelling polymers for biomedical applications, Xian Jun Loh (ed.), 5-35. New York Springer, 2015. 

E. Ruel-Gariepy, J.C. Leroux, In situ-forming hydrogels Review of temperature-sensitive systems, European Journal of Pharmaceutics and Biopharmaceutics, 58,409-26,2004. 

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