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Phosphate cyclic

The hydrolysis of RNA catalyzed by RNase A occurs in two distinct steps, with a 2, 3 -phosphate cyclic diester intermediate (see fig. 8.12). The intermediate can be identified relatively easily, because its breakdown is much slower than its formation. Ribonucleases do not hydrolyze DNA, which lacks the 2 -hydroxyl group needed for the formation of the cyclic intermediate. [Pg.165]

The dependence of kcat of RNase A on pH. The bell-shaped curve suggests that one histidine residue must be in the protonated state and another must be unprotonated. Similar pH dependences are found for the hydrolysis of either RNA or pyrimidine nucleoside-2, 3 -phosphate cyclic diesters. [Pg.166]

Ribonuclease A hydrolyzes RNA adjacent to pyrimidine bases. The reaction proceeds through a 2, 3 -phosphate cyclic diester intermediate. Formation and breakdown of the cyclic diester appear to be promoted by concerted general-base and general-acid catalysis by two histidine residues, and by electrostatic interactions with two lysines. These reactions proceed through pentavalent phosphoryl intermediates. The geometry of these intermediates resembles the geometry of vanadate compounds that act as inhibitors of the enzyme. [Pg.172]

Nucleoside 3, 5 -cyclic phosphate Phosphate Cyclic nucleotide phosphodiesterase (EC 3.1.4.17) 7.5 Nucleoside 5 -phosphate... [Pg.30]

Banwell plan (2008) for oseltamivir phosphate cyclic carbamate and aziridine rings made in step 5, aziridine ring opened in step 6, and cyclic carbamate ring opened in step 7. [Pg.791]

Roche G5 (2008) plan for oseltamivir phosphate cyclic carbamate ring opening (step 9). [Pg.801]

ATP was isolated from the muscle of rabbits [5], and its chemical structure was reported initially by a Japanese scientist [6]. Among the adenosine derivatives, cyclic 3, 5 -adenosine mono phosphate (cyclic AMP/cAMP) is an important alkaloid contained in animal cells as an energy in various chemical and biological activities. [Pg.197]

The cyclic product is extremely sensitive to moisture (hydrolysis) and was more readily isolated as the cyclic diester. An interesting correlation has been observed the phenyl triesters of high energy cyclic phosphates (cyclic nucleotides, ethylene phosphate) are very reactive species, susceptible to decomposition. On the other hand, the phenyl triesters of low energy cyclic phosphates are stable, crystalline compounds. Hence, for example, the phenyl triester of trimethylene phosphoric acid is a crystalline compound readily prepared in high yield by reaction of 1,3-propanediol with phenyl phosphorodichloridate. [Pg.135]

SUSSMAN, K. E. and VAUGHAN, G. D. (1967) Insulin release after ACTH, glucagon and adenosine-3 -5 -phosphate (cyclic AMP) in the perfused isolated rat pancreas. Diabetes. 16. 449. [Pg.360]

A. common point of action in adipose tissue for the lipolytic hormones is the adenyl-cyclase system (Sutherland et al. 196 ) an enzyme probably located on the cell membrane (Davoren and Sutherland, 1963) which catalyses the synthesis of adenosine 3 5 phosphate (cyclic 3 5 AMP). [Pg.426]

When the second substituent in the phosphate is another phosphate instead of an alkyl group, formation of the cyclic compound occurs under mild alkaline treatment. Thus, uridine diphosphate glucose yields uridine monophosphate and glucose cyclic i 2-phosphate and 5-phosphoribosyl P5U ophosphate gives ribose 5-phosphate cyclic i 2-phosphate and inorganic phosphate. Similar changes occur with cytidine diphosphate ribitol and cytidine diphosphate glycerol . [Pg.128]

It seems likely that the metabolic effects of several hormones are mediated by adenosine 3, 5 -phosphate (cyclic AMP). The biochemical effects of this nucleotide have been discussed. 3-92 Cyclic AMP is synthesized from ATP by a reaction catalyzed by adenyl cyclase and it is rapidly inactivated by a cyclic 3, 5 -nucleotide phosphodiesterase which converts it to 5 -AMP.91 Cyclic AMP levels are Influenced by numerous hormones, (catecholamines, glucagon, ACTH, Insulin, and others).91 Most of these stimulate adenyl cyclase and Increase cyclic AMP levels, however, insulin... [Pg.163]


See other pages where Phosphate cyclic is mentioned: [Pg.89]    [Pg.59]    [Pg.641]    [Pg.144]    [Pg.752]    [Pg.176]    [Pg.422]    [Pg.423]    [Pg.312]    [Pg.169]    [Pg.279]    [Pg.291]    [Pg.149]    [Pg.310]    [Pg.313]    [Pg.111]    [Pg.284]    [Pg.485]    [Pg.251]    [Pg.192]    [Pg.254]    [Pg.132]    [Pg.246]   
See also in sourсe #XX -- [ Pg.91 ]

See also in sourсe #XX -- [ Pg.148 , Pg.149 , Pg.153 ]

See also in sourсe #XX -- [ Pg.91 ]

See also in sourсe #XX -- [ Pg.99 ]

See also in sourсe #XX -- [ Pg.91 , Pg.98 ]




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3 , 5 -cyclic phosphate diesterase

3 ,5 -Cyclic adenyl phosphate

3 ,5 -Cyclic adenyl phosphate 3 ,5 -CAMP)

3 ,5 -cyclic phosphate diesterase and

3 ,5 -cyclic phosphate hydrolysis

Adenosine 2 ,3 -cyclic phosphate

Adenosine 3 ,5 -cyclic phosphate, hydrolysis

Adenosine cyclic 2 ,3 -phosphate preparation

Adenosine cyclic 3 ,5 -phosphate assay

Biological chemistry of phosphate esters cyclic substrates and transition states

Brain 3 ,5 -cyclic phosphate diesterase

Catalysis cyclic phosphate formation

Catechol cyclic phosphate

Cyclic Phosphonates and Caged Bicyclic Phosphates

Cyclic adenosine 5 -phosphate receptor

Cyclic phosphate diester

Cyclic-2 .3 -ribose phosphate

Cytidine, 3 ,5 -cyclic phosphate, hydrolysis

Cytidine-2 ,3 -cyclic phosphate

Diribonucleoside 2 ,3 -cyclic phosphate

Enzyme cyclic phosphate ester

Galactose-1,2-cyclic phosphate

Guanosine 2 , 3 -cyclic phosphate

Guanosine, 3 ,5 -cyclic phosphate, hydrolysis

Guanylic acid, 35 -cyclic phosphate

Heart 3 , 5 -cyclic phosphate diesterase

Inosine 35 -cyclic phosphate

Nucleoside 3 ,5 -cyclic dinucleoside phosphates

Nucleoside 3 ,5 -cyclic phosphate

Nucleoside 3 ,5 -cyclic phosphate diesterase

Nucleoside cyclic 3 ,5 -phosphates, preparation

Phosphate ester, cyclic

Phosphate group cyclic ester formation

Phosphates with Cyclic Anions. The Metaphosphates

Phosphates, cyclic linear

Productive intermediates cyclic phosphate intermediate

Ribonuclease cyclic phosphate intermediate

Ribonucleoside 2 , 3 -cyclic phosphate

Ribonucleoside 2 , 3 -cyclic phosphate activity

Ribonucleoside 2 , 3 -cyclic phosphate diesterase

Ribonucleoside cyclic 2 ,3 -phosphates preparation

Ribonucleosides 2 :3 -cyclic phosphates

Ribonucleotide 2 ,3 -cyclic phosphate

Ribonucleotide 2 ,3 -cyclic phosphate diesterase and

Sodium cytidine 2 ,3 -cyclic phosphate

Theophylline, 3 , 5 -cyclic phosphate

Thymidine 3 ,5 -cyclic phosphate

Thymidine 3 ,5 -cyclic phosphate, hydrolysis

Uridine 2 :3 -cyclic phosphate

Uridine cyclic 3 ,5 -phosphate, preparation

Uridine, 3 ,5 -cyclic phosphate, hydrolysis

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