Additives dosing

Immediate treatment of an exposed individual is essential. The U.S. regimen includes the pretreatment, and after exposure atropine and 2-PAM are self-adininistered. Eurther treatment includes up to two additional doses, followed by the tranquilizer VaHum. As required, artificial respiration is instituted, clearing the airway if necessary. The current standard U.S. Army atropine item is the automatic injector, Atropen, designed for self-adininistration by the individual in the field. 

It is important to use the tetracyclines cautiously in patients witii renal function impairment, hi addition, doses greater that 2 g d can be extremely damaging to die liver. The nurse should carefully check die expiration dates of die tetracyclines before administration because degradation of the tetracyclines can occur after degradation, the agents are highly toxic to the kidneys. 

Although rare, benzodiazepine toxicity may occur from an overdose of the drug. Benzodiazepine toxicity causes sedation, respiratory depression, and coma. Flumazenil (Romazicon) is an antidote (antagonist) for benzodiazepine toxicity and acts to reverse die sedation, respiratory depression, and coma within 6 to 10 minutes after intravenous administration. The dosage is individualized based on the patient s response, widi most patients responding to doses of 0.6 to 1 mg. However, die drug s action is short, and additional doses may be needed. Adverse reactions of flumazenil include agitation, confusion, seizures, and in some cases, symptoms of benzodiazepine withdrawal. Adverse reactions of flumazenil related to the symptoms of benzodiazepine withdrawal are relieved by die administration of die benzodiazepine. 

Artificially acquired immunity against some diseases may require periodic booster injections to keep an adequate antibody level (or antibody titer) circulating in the blood. A booster injection is the administration of an additional dose of die vaccine to boost the production of antibodies to a level diat will maintain die desired immunity. The booster is given months or years after die initial vaccine and may be needed because die life of some antibodies is short. 

Patients who experience severe systemic or neurologic reactions after a previous dose of the vaccine should not be given any additional doses. 

Material containing conventional vulcanization system, once formed (e.g., profile) is normally cured immediately. If the product is off-size, or undercured, it is not possible to run again. In the case of EB-cross-Iinked equivalent, the product, in the case of being undercured, can be treated with additional dose to make up to the required level. Hence, EB-processing of polymers is expected to generate less scrap [47]. 

Administered at specific intervals with additional doses given as needed... 

Diazepam 10-20 mg enterally initially to provide sedation ° Titrate additional doses every 5-15 min until goal achieved ° Then allow the drug level to taper through metabolism... 

Loading dose - 20 mg IV over 30 min x one dose. Evaluate response and need for additional doses or continuous IV infusion... 

Although an initial dose of 160 to 325 mg is required to achieve rapid platelet inhibition, long-term therapy with doses of 75 to 150 mg daily are as effective as higher doses. In addition, doses of less than 325 mg daily are associated with a lower rate of bleeding.29,30 The major bleeding rate associated with chronic aspirin administration in doses less than 100 mg per day is 1.6%, whereas the rate with doses more than 100 mg per day is 2.3%.30 Therefore, a daily maintenance dose of 75 to 160 mg is recommended.2... 

Verapamil Inhibits AV nodal conduction by slowing AV nodal conduction and prolonging AV nodal refractoriness 1. 5-10 mg IV over 2-3 minutes 2. If necessary, an additional dose of 5-1 0 mg may be administered 30 minutes later 120-360 mg/day Inhibits digoxin elimination... 

Studies have not shown benefit for additional doses of antibiotic and the duration of antimicrobial prophylaxis should not exceed 24 hours. 

The National Surgical Infection Prevention Project and published evidence suggest that the continuation of antimicrobial prophylaxis beyond wound closure is unnecessary.1 Studies have not shown benefit for additional doses of antibiotic and the duration of antimicrobial prophylaxis should not exceed 24 hours. Longer durations of antibiotic prophylaxis are advocated by some guidelines and will be discussed later. 

Additional doses of atropine and 2-PAMC1 depending on severity. Diazepam or lorazepam to prevent seizures if >4 mg atropine given ventilatory support. 

Kytril 1 mg PO/IV 30 minutes before chemotherapy and Q12H for 3 additional doses... 

In addition, Dose and Seitz (2005) employed native chemical ligation to synthesize peptide nucleic acids (PNAs) by linking shorter segments of PNAs to make long contiguous strands, which could not be made through typical oligo synthesis procedures. 

Q. Just a moment. Professor. I will ask further questions to give you a chance to elaborate. May I ask you What kinds of tests did you think were contemplated for those 50 additional doses, after the report that the 3000 were unsatisfactory ... 

After a pause, Duke nodded "You want to know what was so special about the 50 additional doses of vaccine upon which the scientists were so willing to rely Nothing at all — unless it was intended to use these 50 doses on persons who were sure to get typhus."... 

IV colchicine should be avoided because it is associated with serious adverse effects (e.g., bone marrow suppression, tissue necrosis from local extravasation, disseminated intravascular coagulation, hepatocellular toxicity, and renal failure). If considered necessary, the recommended initial IV dose is 2 mg (if renal function is normal) diluted in 10 to 20 mL of normal saline administered slowly over 10 to 20 minutes in a secure, free-flowing IV line to avoid extravasation. This may be followed by two additional doses of 1 mg each at 6-hour intervals, with the total dose not exceeding 4 mg. After a full IV course, patients should not receive colchicine by any route for at least 7 days. 

Lidocaine can be considered an alternative to amiodarone in patients with VF/ PVT, The initial dose is 1-1,5 mg/kg IV. Additional doses of 0.5-0.75 mg/kgcan be administered at 5-to 10-minute intervals to a maximum dose of 3 mg/kg if VF/PVT persists. 

Labetalol can be given in a dose of200 to 400 mg, followed by additional doses every 2 to 3 hours. 

Infliximab is used for moderate to severe active Crohn s disease in patients failing immunosuppressive therapy, in those who are corticosteroid dependent, and for treatment of fistulizing disease. A single, 5 mg/kg infusion is effective when given every day for 8 weeks. Additional doses at 2 and 6 weeks following the initial dose results in higher response rates. Adalimumab is effective in 54% of patients with moderate to severe Crohn s disease who have lost response to infliximab. The typical dosage is 160 mg subcutaneously initially, followed by 80 mg subcutaneously at week 2, with subsequent doses of 40 mg subcutaneously every other week thereafter. 

Additional doses of tetanus toxoid are recommended as part of traumatic wound management if a patient has not received a dose of tetanus toxoid within the preceding 5 years (Table 51-3). 

Intramuscular (IM) lorazepam, 2 mg, as needed in combination with the maintenance antipsychotic may actually be more effective in controlling agitation than using additional doses of the antipsychotic. 

Sequence for Special Metallic Lacquers For some special metallic lacquers it is necessary to perform a pre-dispersion of the basic materials. For this process an additional dose distributor is required for the pre-dispersion resources. The assignment of the dose distributor starts at the same time as the assignment of the pre-dispersion resource. When the pre-dispersion process has finished the procedures on the dose spinner and on the mixer begin. The following production steps are equal to those of the standard production sequence (see Figures 4.8 and 4.9). 

Yes. In 2000, CDC awarded a contract to a vaccine manufacturer to produce additional doses of smallpox vaccine. 

Although GHB is primarily used for recreational purposes, cases of addiction to GHB have been reported. Some GHB users go on binges during which they take GHB around the clock (every 2-4 hours) for a few days. As the user takes additional doses, he or she develops tolerance to the effects of the drug (GHB becomes less effective with subsequent doses, so the user takes even more). Eventually, the binge GHB user exhibits signs of withdrawal, such as anxiety, insomnia, delirium and hallucinations, muscle cramping and tremors, and tachycardia (abnormally fast heart rate). 

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